Mild-to-moderate hyperglycemia will not decrease the sensitivity of 18F-FDG PET imaging in the detection of pedal osteomyelitis in diabetic patients.
Mild-to-moderate hyperglycemia will not decrease the sensitivity of 18F-FDG PET imaging in the detection of pedal osteomyelitis in diabetic patients.
复制标题
轻中度高血糖不会降低 18F-FDG PET 成像检测糖尿病患者足部骨髓炎的敏感性。
DOI：
10.1097/mnm.0000000000000434
复制
发表时间：
2016
影响因子：
1.5
通讯作者：
Alavi,Abass
中科院分区：
文献类型：
--
作者：
Yang,Hua;Zhuang,Hongming;Rubello,Domenico;Alavi,Abass
PurposePedal osteomyelitis is a worrisome complication of diabetic foot disease. Controlling serum glucose levels is difficult for many diabetic patients. High serum glucose levels could potentially affect the results of fluorine-18 fluorodeoxyglucose (18 F-FDG) PET imaging in the detection of osteomyelitis. The aim of this investigation was to determine whether high serum glucose levels diminish the diagnostic accuracy of 18 F-FDG PET imaging in detecting pedal osteomyelitis in diabetic patients.Materials and methodsForty-eight consecutive diabetic patients with a suspicion of pedal osteomyelitis were included in this investigation. At the time of 18 F-FDG administration, 21 patients had serum glucose levels less than 150 mg/dl (group A), and 27 had serum glucose levels greater than 150 mg/dl (group B). Results of PET imaging were compared with final diagnostic outcome based on histopathology and/or 12 months’ clinical follow-up.ResultsOsteomyelitis was confirmed in 17 patients. 18 F-FDG PET correctly detected osteomyelitis in 15 of 17 patients for a sensitivity of 88.3%(15/17). This technique successfully excluded osteomyelitis in 30 of 31 cases for a specificity of 96.8%(30/31) and an overall accuracy of 93.8%(45/48). The sensitivity of 18 F-FDG PET imaging was 87.5%(7/8) in patients with serum glucose levels less than 150 mg/dl (group A) and 88.9%(8/9) in patients with serum glucose levels greater than 150 mg/dl (group B). These results do not significantly differ from the overall sensitivity of 88.3%(15/17).ConclusionMildly to moderately elevated serum glucose levels do not adversely affect the accuracy of 18 F-FDG PET imaging in the detection of pedal osteomyelitis in diabetic patients.
