Rheological Characterization of Alginate Based Hydrogels for Tissue Engineering
Rheological Characterization of Alginate Based Hydrogels for Tissue Engineering
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DOI：
10.1557/adv.2017.8
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发表时间：
2017-01-01
期刊：
影响因子：
0.8
通讯作者：
Chen, Jinju
中科院分区：
文献类型：
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作者：
Duan, Pengfei;Kandemir, Nehir;Chen, Jinju
水凝胶已被广泛应用于从组织工程到药物输送系统的许多领域。对于组织工程和药物输送来说，力学性能都很重要，因为它们会影响水凝胶载体中细胞-材料的相互作用和药物的可注射性。因此，研究这些水凝胶的力学性能，特别是在生理温度(37摄氏度)下的力学性能是很重要的。本研究采用应变扫描和频率扫描旋转流变学试验，研究了不同浓度的组织工程相关水凝胶在37℃下的流变特性。这些水凝胶包括海藻酸盐、RGD-海藻酸盐和共聚胶原/海藻酸盐/纤维蛋白。结果表明，RGD的加入对海藻酸盐的弹性模量和粘度影响不大。藻酸盐凝胶表现出剪切变稀行为，这表明它们是适合作为细胞或药物输送载体的候选材料。胶原和纤维蛋白的加入将增强海藻酸盐的力学性能，使其成为一种坚固的支架材料。
Hydrogels have been widely used in many applications from tissue engineering to drug delivery systems. For both tissue engineering and drug delivery, the mechanical properties are important because they would affect cell-materials interactions and injectability of drugs encapsulated in hydrogel carriers. Therefore, it is important to study the mechanical properties of these hydrogels, particularly at physiological temperature (37 degrees C). This study adopted strain sweep and frequency sweep rotational rheological tests to investigate the rheological characteristics of various tissue engineering relevant hydrogels with different concentrations at 37 degrees C. These hydrogels include alginate, RGD-alginate, and copolymerized collagen/alginate/fibrin. It has revealed that the addition of RGD has negligible effect on the elastic modulus and viscosity of alginate. Alginate gels have demonstrated shear thinning behavior which indicates that they are suitable candidates as carriers for cells or drug delivery. The addition of collagen and fibrin would reinforce the mechanical properties of alginate which makes it a strong scaffold material.