Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases

Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases
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益生菌在预防和治疗炎症性肠病中的潜在应用

DOI:
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发表时间:
2011
期刊:
影响因子:
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通讯作者:
J. LeBlanc
J. LeBlanc
中科院分区:
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文献类型:
--
作者:
S. D. Carmen;A. LeBlanc;A. Miyoshi;C. S. Rocha;V. Azevedo;J. LeBlanc

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乳酸菌(LAB)代表了一组天然存在于许多食品中的异质微生物,具有广泛的治疗特性。本文的目的是提出一个概述,目前扩大知识的机制,LAB和其他益生菌微生物参与预防和治疗炎症性肠病。这些包括肠道微生物群的变化,刺激宿主免疫反应,以及由于其抗氧化特性而减少氧化应激。还将讨论基因工程LAB产生抗氧化酶(如过氧化氢酶和超氧化物歧化酶)或抗炎细胞因子(如IL-10)的用途的简要概述。本文将表明,益生菌应考虑在IBD的治疗方案,因为它们提供了许多有益的效果,可以提高传统使用的药物的有效性。
Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of inflammatory bowel diseases. These include changes in the gut microbiota, stimulation of the host immune responses, and reduction of the oxidative stress due to their antioxidant properties. A brief overview of the uses of genetically engineered LAB that produce either antioxidant enzymes (such as catalase and superoxide dismutase) or anti-inflammatory cytokines (such as IL-10) will also be discussed. This paper will show that probiotics should be considered in treatment protocols of IBD since they provide many beneficial effects and can enhance the effectiveness of traditional used medicines.
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