A novel anticancer agent icaritin inhibited proinflammatory cytokines in TRAMP mice
A novel anticancer agent icaritin inhibited proinflammatory cytokines in TRAMP mice
复制标题
新型抗癌剂淫羊藿素可抑制 TRAMP 小鼠的促炎细胞因子
DOI：
10.1007/s11255-016-1341-9
复制
发表时间：
2016-10-01
影响因子：
2
通讯作者：
Jiang, Haowen
中科院分区：
文献类型：
--
作者：
Hu, Jimeng;Yang, Tian;Jiang, Haowen
PurposeWe aimed to investigate whether icaritin (ICT) would inhibit serum proinflammatory cytokines and postpone prostate cancer (PCa) development and progression in both normal diet and high-fat diet (HFD) transgenic adenocarcinoma mouse prostate (TRAMP) mice.MethodsTRAMP mice were randomly divided into four groups: normal diet with/without ICT group and HFD with/without ICT group. Each TRAMP mouse received intraperitoneal injection of ICT solution at the dose of 30 mg/kg 5 times per week.ResultsICT treatment could significantly increase the survival when compared with those in normal diet group (P= 0.015, log-rank test) and HFD group (P= 0.009, log-rank test). Proinflammatory cytokine levels, including IL-1α, IL-1β, IL-6, and TNF-α, were decreased more or less in ICT-treated TRAMP mice. Moreover, significant higher inflammation scores were detected in normal diet group and HFD group compared with their relevant ICT treatment groups (P= 0.026 andP= 0.006, respectively). Meanwhile, the incidences of well-differentiated tumor tissue in two ICT treatment groups (39.13 and 31.82 %) were moderately higher than control groups (29.41 and 20.00 %, respectively), though no significant difference was observed.ConclusionsTaken together, our findings indicate that ICT could inhibit the development and progression of PCa in TRAMP mice via inhibiting proinflammatory cytokines.
