Intestinal and hepatic drug transporters: pharmacokinetic, pathophysiological, and pharmacogenetic roles.
Intestinal and hepatic drug transporters: pharmacokinetic, pathophysiological, and pharmacogenetic roles.
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肠和肝药物转运蛋白：药代动力学、病理生理学和药物遗传学作用。
DOI：
10.1007/s00535-015-1061-4
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发表时间：
2015
影响因子：
6.3
通讯作者：
Daiki Hira.
中科院分区：
文献类型：
--
作者：
Tomohiro Terada;Daiki Hira.
药物治疗的有效性和安全性取决于药物与人体相互作用的复杂过程，包括药代动力学方面。药物转运蛋白在药物的吸收、分布和排泄过程中起着重要的作用，调节药物的膜转运。在过去的20年中收集了大量的信息，药物转运蛋白已组织根据生化，分子，遗传和临床分析。新技术、公共数据库和监管指南促进了这些信息在药物开发和临床实践中的应用。本文就近年来在肠道和肝脏中表达的一些重要的药物转运蛋白，介绍了它们的药代动力学、病理生理学和药物遗传学的研究历史和现状。
The efficacy and safety of pharmacotherapies are determined by the complex processes involved in the interactions between drugs with the human body, including pharmacokinetic aspects. Among pharmacokinetic factors, it has been recognized that drug transporters play critical roles for absorption, distribution and excretion of drugs, regulating the membrane transport of drugs. The vast amounts of information on drug transporters collected in the past 20 years have been organized according to biochemical, molecular, genetic, and clinical analyses. Novel technologies, public databases, and regulatory guidelines have advanced the use of such information in drug development and clinical practice. In this review, we selected some clinically important drug transporters expressed in the intestine and liver, and introduced the research history and current knowledge of their pharmacokinetic, pathophysiological, and pharmacogenetic implications.