EFFECTS OF VARYING CARBOHYDRATE CONTENT OF DIET IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS
EFFECTS OF VARYING CARBOHYDRATE CONTENT OF DIET IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS
复制标题
DOI：
10.1001/jama.271.18.1421
复制
发表时间：
1994-05-11
影响因子：
120.7
通讯作者：
REAVEN, GM
中科院分区：
文献类型：
--
作者：
GARG, A;BANTLE, JP;REAVEN, GM
客观。-目的：研究饮食中碳水化合物含量变化对非胰岛素依赖型糖尿病（NIDDM）患者血糖和血脂的影响。四中心随机交叉试验。设置。-代谢单位的门诊和住院患者评价。42例接受格列吡嗪治疗的NIDDM患者。一种高碳水化合物饮食含有55%的总能量作为碳水化合物和30%的脂肪，与含有40%碳水化合物和45%脂肪的高单不饱和脂肪饮食进行比较。饱和脂肪、多不饱和脂肪、胆固醇、蔗糖和蛋白质的含量相似。在代谢厨房中制备的研究饮食作为唯一营养素提供给受试者，每次持续6周。为了评估长期效果，一个由21名患者组成的亚组继续他们第二次接受的饮食，再持续8周。空腹血糖、胰岛素、脂蛋白和糖化血红蛋白浓度。24小时血糖、胰岛素和甘油三酯水平曲线。研究部位和饮食顺序不影响结果。与高单不饱和脂肪饮食相比，高碳水化合物饮食使空腹血浆甘油三酯水平和极低密度脂蛋白胆固醇水平增加了24%（P
Objective.-To study effects of variation in carbohydrate content of diet on glycemia and plasma lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM).Design.-A four-center randomized crossover trial.Setting.-Outpatient and inpatient evaluation in metabolic units.Patients.-Forty-two NIDDM patients receiving glipizide therapy.Interventions.-A high-carbohydrate diet containing 55% of the total energy as carbohydrates and 30% as fats was compared with a high-monounsaturated-fat diet containing 40% carbohydrates and 45% fats. The amounts of saturated fats, polyunsaturated fats, cholesterol, sucrose, and protein were similar. The study diets, prepared in metabolic kitchens, were provided as the sole nutrients to subjects for 6 weeks each. To assess longer-term effects, a subgroup of 21 patients continued the diet they received second for an additional 8 weeks.Main outcome Measures.-Fasting plasma glucose, insulin, lipoproteins, and glycosylated hemoglobin concentrations. Twenty-four-hour profiles of glucose, insulin, and triglyceride levels.Results.-The site of study as well as the diet order did not affect the results. Compared with the high-monounsaturated-fat diet, the high-carbohydrate diet increased fasting plasma triglyceride levels and very low-density lipoprotein cholesterol levels by 24% (P