The control of filamentous differentiation and virulence in fungi
The control of filamentous differentiation and virulence in fungi
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DOI：
10.1016/s0962-8924(98)01298-7
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发表时间：
1998-09-01
影响因子：
19
通讯作者：
Fink, GR
中科院分区：
文献类型：
--
作者：
Madhani, HD;Fink, GR
真菌王国的许多成员都有一个显着的特征，即二型性，这是在两种形态形式之间切换的能力：细胞酵母形式和多细胞侵入性丝状形式。在芽殖酵母酿酒酵母中，至少有三种途径参与调节这两种形式之间的转换，现在有证据表明，同源信号传导模块参与调节一系列人类和植物真菌病原体中的丝状体形成和毒力。引人注目的是，用于响应交配信息素的信号性分化的组件往往被重新利用，以调节二态发育，这表明这些过程之间的古老联系。
Many members of the fungal kingdom have a distinguishing feature, dimorphism, which is the ability to switch between two morphological forms: cellular yeast form and a multicellular invasive filamentous form. At least three pathways are involved in regulating the transition between these two forms in the budding yeast Saccharomyces cerevisiae, and evidence is now emerging that homologous signalling modules are involved in regulating filament formation ann virulence in a range of human and plant fungal pathogens. Strikingly, components used to signal sexual differentiation in the response to mating pheromones are often reutilized to regulate dimorphic development, suggesting an ancient link between these processes.