Reparative inflammation takes charge of tissue regeneration.
Reparative inflammation takes charge of tissue regeneration.
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DOI：
10.1038/nature17039
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发表时间：
2016-01-21
期刊：
影响因子：
64.8
通讯作者：
Clevers H
中科院分区：
文献类型：
--
作者：
Karin M;Clevers H
炎症是许多慢性和退行性疾病的基础，但它也减轻感染，清除受损细胞并启动组织修复。许多在哺乳动物中将炎症与损伤修复和再生联系起来的机制在低等生物中是保守的，这表明它是一个进化上重要的过程。最近的见解揭示了细胞和分子过程，通过传统的炎症细胞因子和Wnt因子控制哺乳动物组织修复和再生。这对于胃肠系统中的再生特别重要，尤其是对于肠和肝组织，其中异常和失调的修复导致严重的病理。
Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.