The association of sleep duration and sleep quality with non-alcoholic fatty liver disease in a Taiwanese population
The association of sleep duration and sleep quality with non-alcoholic fatty liver disease in a Taiwanese population
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DOI：
10.1016/j.orcp.2018.05.002
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发表时间：
2018-11-01
影响因子：
4.3
通讯作者：
Lu, Feng-Hwa
中科院分区：
文献类型：
--
作者：
Chou, Yu-Tsung;Cheng, Hsiang-Ju;Lu, Feng-Hwa
目的：睡眠持续时间/质量与非酒精性脂肪性肝病（NAFLD）的关系尚不确定。在一些研究中，几个重要的协变量没有同时调整，并且没有考虑NAFLD的严重程度。此外，睡眠时间或睡眠质量对NAFLD的性别影响仍不清楚。因此，我们的目的是研究协会的睡眠时间和质量与NAFLD的性别在Taiwan population.Methods：共6663名年龄在18岁或以上的受试者参加。根据超声检查结果将NAFLD的严重程度分为轻度、中度和重度。睡眠时间分为三组：短（8小时）。采用匹兹堡睡眠质量指数（PSQI）评价睡眠质量，PSQI总分大于5分定义为睡眠质量差。结果：校正潜在混杂因素后，多项Logistic回归分析显示睡眠质量差与男性轻、中重度NAFLD均呈负相关，但睡眠时间与NAFLD无独立相关性。在女性中，睡眠状况与NAFLD无关。结论：睡眠质量差而不是睡眠时间与男性中中度至重度NAFLD和轻度NAFLD的风险较低相关。在女性中，睡眠质量和持续时间与NAFLD风险的相关性不显著。(C)2018亚洲大洋洲肥胖研究协会。由爱思唯尔有限公司出版。保留所有权利。
Objective: The association of sleep duration/quality with nonalcoholic fatty liver disease (NAFLD) is inconclusive. Several important covariates were not adjusted concomitantly in some studies, and the severity of NAFLD was not considered. Furthermore, the gender impact of sleep duration or sleep quality on NAFLD remains unclear. We thus aimed to examine the association of sleep duration and quality with NAFLD by gender in a Taiwanese population.Methods: A total of 6663 subjects aged 18 years or more were enrolled. The severity of NAFLD was divided into mild, moderate, and severe degrees based on ultrasound findings. The sleep duration was classified into three groups: short (8 h). Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and poor sleep quality was defined as a global PSQI score greater than 5.Results: After adjustment for potential confounders, multinomial logistic regression showed that poor sleep quality was negatively associated with both mild and moderate-to-severe NAFLD in males, but sleep duration was not independently related to NAFLD. In females, sleep condition was not related to NAFLD.Conclusions: Poor sleep quality but not sleep duration was associated with a lower risk of not only moderate to severe but also mild NAFLD in males. In females, the association of sleep quality and duration with the risk of NAFLD was insignificant. (C) 2018 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.