Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses' Health Study.
Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses' Health Study.
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DOI：
10.1158/1055-9965.epi-10-0125
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Sagiv SK
中科院分区：
文献类型：
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作者：
Laden F;Bertrand KA;Altshul L;Aster JC;Korrick SA;Sagiv SK
许多研究报告了环境暴露于多氯联苯（PCBs）和p，p′-二氯二苯二氯乙烯（p，p′-DDE）与非霍奇金淋巴瘤（NHL）风险的正相关性。在一项嵌套在护士健康研究中的病例对照研究中，我们测量了145名在抽血后至少6个月被诊断为NHL的女性和290名年龄和种族匹配的对照组的血液样本中的PCB和p，p′-DDE浓度。我们使用条件logistic回归来估计暴露的每个四分位数相对于最低四分位数的比值比（OR）和95%置信区间（CI）。我们还评估了NHL主要组织学亚型的这些相关性。没有一致的证据表明p，p′-DDE、总PCB、免疫毒性或单个PCB同系物与NHL风险相关。这些结果不支持假设的PCB暴露和NHL的发展之间的正相关。
Numerous studies have reported positive associations of environmental exposure to polychlorinated biphenyls (PCBs) and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) with the risk of non-Hodgkin lymphoma (NHL). In a case-control study nested within the Nurses’ Health Study, a prospective cohort of US women, we measured concentrations of PCBs and p,p′-DDE in blood samples from 145 women diagnosed with NHL at least six months after blood draw, and 290 age- and race-matched controls. We used conditional logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for each quartile of exposure relative to the lowest quartile. We also evaluated these associations for major histologic subtypes of NHL. There was no consistent evidence of an association of p,p′-DDE, total PCBs, immunotoxic or individual PCB congeners with risk of NHL. These results do not support the hypothesis of a positive association between PCB exposure and development of NHL.