HUMAN POLYOMAVIRUS INFECTIONS WITH JC VIRUS AND BK VIRUS IN RENAL-TRANSPLANT PATIENTS
HUMAN POLYOMAVIRUS INFECTIONS WITH JC VIRUS AND BK VIRUS IN RENAL-TRANSPLANT PATIENTS
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DOI：
10.7326/0003-4819-92-3-373
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发表时间：
1980-01-01
影响因子：
39.2
通讯作者：
WALKER, DL
中科院分区：
文献类型：
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作者：
HOGAN, TF;BORDEN, EC;WALKER, DL
对61例免疫功能低下的肾移植患者进行了人类多瘤病毒JC病毒和BK病毒感染的研究。尿细胞学检查、间接免疫荧光显微镜检查、EM和血清学检查用于评估病毒活性。从患者记录中提取与多瘤病毒感染相关的事件。61例患者中有12例(20%)尿液中有多瘤病毒排泄。排泄JC病毒11例，BK病毒9例。61例患者中有25例血凝抑制抗体效价升高4倍(41%)。大多数JC病毒感染显然是原发的，而大多数BK病毒感染是病毒重新激活的结果。在这项为期两年的研究中，61名患者中有32名(52%)有病毒复制活跃的证据。尿路排泄与药物依赖型糖尿病(P=0.001.0 5)、动脉闭塞症(P=0.0 3)、输尿管狭窄伴肾功能衰竭(P=0.0 2)有关。BK病毒抗体升高与血肌酸升高(P=0.02)和需要移植肝活检(P=0.02)相关。多瘤病毒复制与移植相关并发症的发生率增加有关。
Infection with the human polyomaviruses JC virus and BK virus was studied in 61 immunosuppressed renal transplant patients. Urine cytologic studies, indirect immunofluorescence microscopy, EM and serologic studies were used to assess viral activity. Patients records were abstracted for events associated with polyomavirus infections. Polyomavirus excretion in urine was detected in 12 of 61 patients (20%). Eleven excreted JC virus and 9, BK virus. Fourfold hemagglutination-inhibition antibody titer rises occurred in 25 of 61 patients (41%). Most JC virus infections apparently were primary, whereas most BK virus infections resulted from virus reactivation. During this 2 yr study, 32 of 61 patients (52%) had evidence of active viral replication. Urinary tract excretion was associated with drug-requiring diabetes mellitus (P = 0.001), arterial occlusive disease (P = 0.03) and ureteral stricture with loss of renal function (P = 0.02). Antibody increases to BK virus were associated with a rising serum creatine (P = 0.02) and need for transplant biopsy (P = 0.02). Polyomavirus replication was associated with an increased frequency of transplant related complications.