Defining myocardial tissue abnormalities in end-stage renal failure with cardiac magnetic resonance imaging using native T1 mapping.
Defining myocardial tissue abnormalities in end-stage renal failure with cardiac magnetic resonance imaging using native T1 mapping.
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DOI：
10.1016/j.kint.2016.06.014
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发表时间：
2016-10
影响因子：
19.6
通讯作者：
Mark, Patrick B.
中科院分区：
文献类型：
--
作者：
Rutherford, Elaine;Talle, Mohammed A.;Mangion, Kenneth;Bell, Elizabeth;Rauhalammi, Samuli M.;Roditi, Giles;McComb, Christie;Radjenovic, Aleksandra;Welsh, Paul;Woodward, Rosemary;Struthers, Allan D.;Jardine, Alan G.;Patel, Rajan K.;Berry, Colin;Mark, Patrick B.
终末期肾病心肌纤维化的非侵入性定量是具有挑战性的。以前用于心脏磁共振成像（MRI）的钆造影剂是禁忌的，因为它与肾源性系统性纤维化有关。在其他人群中，心脏MRI显示心肌天然T1时间增加已被证明是心肌纤维化的替代标志物。我们将该方法应用于33例血液透析患者和28例年龄和性别匹配的健康志愿者，他们在3.0T下接受了MRI。比较了作为纤维化潜在标志物的天然T1弛豫时间和特征跟踪衍生的全局纵向应变，并与心脏生物标志物相关联。血液透析组左心室重量指数高于对照组。血液透析组的总体、间隔和中间间隔T1时间均显著较高（总体T1血液透析1171 ± 27 ms vs. 1154 ± 32 ms;间隔T1血液透析1184 ± 29 ms vs. 1163 ± 30 ms;中间间隔T1血液透析1184 ± 34 ms vs. 1161 ± 29 ms）。在血液透析组中，T1时间与左心室质量指数相关。间隔T1时间与肌钙蛋白和心电图校正的QT间期相关。血液透析组的峰值整体纵向应变显著降低（血液透析组为-17.7 5. 3% vs. -21.8 6. 2%）。对于血液透析患者，峰值全局纵向应变与左心室质量指数显著相关（R = 0.426），并且观察到与半乳糖凝集素-3（心脏纤维化的生物标志物）相关的趋势。因此，血液透析患者的心脏组织特性与心肌纤维化一致，可以无创地确定，并与多种结构和功能异常相关。
Noninvasive quantification of myocardial fibrosis in end-stage renal disease is challenging. Gadolinium contrast agents previously used for cardiac magnetic resonance imaging (MRI) are contraindicated because of an association with nephrogenic systemic fibrosis. In other populations, increased myocardial native T1 times on cardiac MRI have been shown to be a surrogate marker of myocardial fibrosis. We applied this method to 33 incident hemodialysis patients and 28 age- and sex-matched healthy volunteers who underwent MRI at 3.0T. Native T1 relaxation times and feature tracking–derived global longitudinal strain as potential markers of fibrosis were compared and associated with cardiac biomarkers. Left ventricular mass indices were higher in the hemodialysis than the control group. Global, Septal and midseptal T1 times were all significantly higher in the hemodialysis group (global T1 hemodialysis 1171 ± 27 ms vs. 1154 ± 32 ms; septal T1 hemodialysis 1184 ± 29 ms vs. 1163 ± 30 ms; and midseptal T1 hemodialysis 1184 ± 34 ms vs. 1161 ± 29 ms). In the hemodialysis group, T1 times correlated with left ventricular mass indices. Septal T1 times correlated with troponin and electrocardiogram-corrected QT interval. The peak global longitudinal strain was significantly reduced in the hemodialysis group (hemodialysis -17.7±5.3% vs. -21.8±6.2%). For hemodialysis patients, the peak global longitudinal strain significantly correlated with left ventricular mass indices (R = 0.426), and a trend was seen for correlation with galectin-3, a biomarker of cardiac fibrosis. Thus, cardiac tissue properties of hemodialysis patients consistent with myocardial fibrosis can be determined noninvasively and associated with multiple structural and functional abnormalities.
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影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
DOI：
10.1016/j.echo.2011.11.010
发表时间：
2012-01-01
影响因子：
6.5
作者：
Lang, Roberto M.;Badano, Luigi P.;Zoghbi, William A.
通讯作者：
Zoghbi, William A.
影响因子：
19.6
作者：
Mark, P. B.;Johnston, N.;Jardine, A. G.
通讯作者：
Jardine, A. G.
影响因子：
4.4
作者：
Moody, William E.;Taylor, Robin J.;Steeds, Richard P.
通讯作者：
Steeds, Richard P.
影响因子：
19.6
作者：
Aoki, J;Ikari, Y;Hara, K
通讯作者：
Hara, K