R2*imaging of transfusional iron burden at 3T and comparison with 1.5T
R2*imaging of transfusional iron burden at 3T and comparison with 1.5T
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DOI：
10.1002/jmri.20816
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发表时间：
2007-03-01
影响因子：
4.4
通讯作者：
Rigsby, Cynthia K.
中科院分区：
文献类型：
--
作者：
Storey, Pippa;Thompson, Alexis A.;Rigsby, Cynthia K.
目的：确定 3T 时肝脏和心脏的正常 R2* 值，并在一定范围的组织铁浓度下建立 3T 和 1.5T 时 R2* 之间的关系。 材料和方法：总共 20 名健康对照受试者和 14 名输血依赖患者在 1.5T 和 3T 下进行扫描。在每个场强下，在肝脏和心脏中进行 R2* 成像。结果：根据对照组估计，肝脏中的标准 R2* 值在 1.5T 时为 39.2 +/- 9.0 秒(-1)，在 3T 时为 69.1 +/- 21.9 秒(-)1。正常心脏值在 1.5T 时估计为 23.4 +/- 2.2 秒(-1)，在 3T 时估计为 30.0 +/- 3.7 秒(-1)。来自患者和对照受试者的组合 R2* 数据表现出 3T 和 1.5T 之间的线性关系。在肝脏中，3T 与 1.5T 数据的最佳拟合线的斜率为 2.00 +/- 0.06，截距为 -11 +/- 4 秒 (-1)。在心脏中，其斜率为 1.88 +/- 0.14，截距为 -15 +/- 4 秒(-1)。结论：这些初步数据表明，R2* 的铁依赖性成分在较宽的组织铁浓度范围内与场强呈线性比例关系。然而，磁化率伪影的发生率也可能随着场强的增加而增加。
Purpose: To determine normative R2* values in the liver and heart at 3T, and establish the relationship between R2*at 3T and 1.5T over a range of tissue iron concentrations.Materials and Methods: A total of 20 healthy control subjects and 14 transfusion-dependent patients were scanned at 1.5T and 3T. At each field strength R2* imaging was performed in the liver and heart.Results: Normative R2* values in the liver were estimated from the control group to be 39.2 +/- 9.0 second(-1) at 1.5T and 69.1 +/- 21.9 second(-)1 at 3T. Normative cardiac values were estimated as 23.4 +/- 2.2 second(-1) at 1.5T and 30.0 +/- 3.7 second(-1) at 3T. The combined R2* data from patients and control subjects exhibited a linear relationship between 3T and 1.5T. In the liver, the line of best fit to the 3T vs. 1.5T data had a slope of 2.00 +/- 0.06 and an intercept of -11 +/- 4 second(-1). In the heart, it had a slope of 1.88 +/- 0.14 and an intercept of -15 +/- 4 second(-1).Conclusion: These preliminary data suggest that the iron-dependent component of R2* scales linearly with field strength over a wide range of tissue iron concentrations. The incidence of susceptibility artifacts may, however, also increase with field strength.