Genetic differentiation of the Cabo Verde Archipelago population analysed by STR polymorphisms
Genetic differentiation of the Cabo Verde Archipelago population analysed by STR polymorphisms
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DOI：
10.1046/j.1469-1809.2003.00029.x
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发表时间：
2003-07-01
影响因子：
1.9
通讯作者：
Brehm, A
中科院分区：
文献类型：
--
作者：
Fernandes, AT;Velosa, R;Brehm, A
对佛得角群岛无血缘关系的男性样本中17个STR基因座的等位基因频率进行了分析。样本的收集方式是这样一种方式，即完全确定了受试者的来源，并将它们归入背风或迎风的岛屿群中。这项研究表明，这两组岛屿之间以及佛得角人与撒哈拉以南非洲的其他人口(包括几内亚人)之间存在显著差异，几内亚人是佛得角人最可能的来源人口。这项研究证实了线粒体DNA数据，并结合已经公布的人类白细胞抗原和Y染色体数据，表明佛得角人口是亚结构和非典型的，与撒哈拉以南非洲大陆人口有很大差异。总体而言，这些差异很可能是由于带入岛屿的撒哈拉以南奴隶和其他欧洲血统的定居者之间的混杂。在没有明确迹象表明第一批佛得角撒哈拉以南定居者的种族构成不同的情况下，这两组岛屿表现出的差异很可能归因于遗传漂移。
Allele frequencies for 17 STR loci were analyzed in a sample of unrelated males from the Cabo Verde Archipelago. The samples were gathered in such a way that the origin of the subjects was perfectly identified, and they could be included in one of the leeward or windward groups of islands. This study reveals that there are significant differences between both groups of islands, and between Cabo Verdeans and other populations from sub-Sahara Africa including the Guineans, the most probable source population for Cabo Verdeans. This study confirms mtDNA data and, together with HLA and Y chromosome data already published, shows that the Cabo Verde population is substructured and atypical, diverging substantially from mainland sub-Saharan populations. Overall these differences are most probably due to admixture between sub-Saharan slaves brought into the islands and other settlers of European origin. In the absence of a clear indication of a different ethnic composition of the first sub-Saharan settlers of Cabo Verde, the differentiation exhibited in both groups of islands can be most probably be attributed to genetic drift.