Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats
Myocardial hypertrophy and enhanced left ventricular contractility in Zucker diabetic fatty rats
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DOI：
10.1016/s1054-8807(03)00109-1
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发表时间：
2004-01-01
影响因子：
3.7
通讯作者：
Weil, J
中科院分区：
文献类型：
--
作者：
Fredersdorf, S;Thumann, C;Weil, J
众所周知，即使在没有冠心病或高血压的情况下，心力衰竭也是胰岛素依赖型（IDDM）和非胰岛素依赖型糖尿病（NIDDM）的并发症。导致糖尿病心肌病的机制尚不清楚。该研究的目的是表征用或不用胰岛素治疗的高胰岛素血症 Zucker 糖尿病脂肪 (ZDF) 大鼠的结构和功能变化。与非糖尿病同窝动物相比，糖尿病发病后 2 个月，尽管血浆肾素活性 (PRA) 降低，但糖尿病动物的心肌细胞体积增加了一倍，左心室 ANP 增加，但 BNP mRNA 水平没有增加。这些变化与超声心动图评估的左心室性能增加相关。胰岛素治疗导致体重（BW）、心脏总重、心肌蛋白含量和左心室质量（LVM）显着增加。无论是否进行胰岛素治疗，糖尿病大鼠心肌中血管周围纤维化和层粘连蛋白厚度均显着增加，而在糖尿病和对照心肌中也类似地发现了间质胶原 I 和纤连蛋白。高胰岛素血症大鼠糖尿病心肌病的初始阶段的特征是心肌细胞肥大和心肌收缩力增强。提示高胰岛素血症可能与心脏肥大有关。 (C) 2004 Elsevier Inc. 保留所有权利。
Heart failure is known to be a complication of insulin-dependent (IDDM) and noninsulin-dependent diabetes mellitus (NIDDM) even in the absence of coronary heart disease or hypertension. The mechanisms leading to diabetic cardiomyopathy are unknown. The aim of the study was to characterize structural and functional alterations in hyperinsulinemic Zucker diabetic fatty (ZDF) rats treated with or without insulin. Diabetic animals showed a twofold increase in cardiomyocyte volume with increased left ventricular ANP but not BNP mRNA levels in spite of a reduced plasma renin activity (PRA) 2 months after onset of diabetes compared to nondiabetic littermates. These changes were associated with an increase in left ventricular performance as assessed by echocardiography. Insulin treatment led to a significant increase in body weight (BW), total heart weight, myocardial protein content, and left ventricular mass (LVM). Perivascular fibrosis and laminin thickness were significantly augmented in diabetic rat myocardium irrespective of insulin treatment, whereas interstitial collagen I and fibronectin were similarly found in diabetic and control myocardium. Initial stages of diabetic cardiomyopathy in hyperinsulinemic rats are characterized by cardiomyocyte hypertrophy and enhanced cardiac contractility. It is suggested that hyperinsulinemia may be involved in cardiac hypertrophy. (C) 2004 Elsevier Inc. All rights reserved.