Biocompatibility and stability of disulfide-crosslinked hyaluronan films
Biocompatibility and stability of disulfide-crosslinked hyaluronan films
复制标题
DOI：
10.1016/j.biomaterials.2005.01.003
复制
发表时间：
2005-08-01
期刊：
影响因子：
14
通讯作者：
Prestwich, GD
中科院分区：
文献类型：
--
作者：
Liu, YC;Shu, XZ;Prestwich, GD
透明质酸（HA）可以通过化学修饰来设计具有预先选择的机械性能和可由预期临床用途决定的吸收率的坚固材料。采用空气氧化法制备了巯基羟基磷灰石交联膜。然后用0.3%过氧化氢处理。二硫交联膜在体外降解非常缓慢(
Hyaluronan (HA) can be chemically modified to engineer robust materials with pre-selected mechanical properties and resorption rates that can be dictated by the intended clinical use. Disulfide-crosslinked HA films were prepared by air oxidation of thiol-modified HA. followed by treatment with 0.3% hydrogen peroxide. The degradation of the disulfide-crosslinked films in vitro was very slow (