Construction of self-assembled polyelectrolyte complex hydrogel based on oppositely charged polysaccharides for sustained delivery of green tea polyphenols
Construction of self-assembled polyelectrolyte complex hydrogel based on oppositely charged polysaccharides for sustained delivery of green tea polyphenols
复制标题
基于带相反电荷多糖的自组装聚电解质复合水凝胶的构建用于绿茶多酚的持续递送
DOI：
10.1016/j.foodchem.2019.125632
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发表时间：
2020-02-15
期刊：
影响因子：
8.8
通讯作者：
Xu, Man
中科院分区：
文献类型：
--
作者：
Hu, Xinyu;Wang, Yongmei;Xu, Man
在这项研究中，我们开发了一种新型聚电解质复合物（PEC）水凝胶，可以通过两种食品级多糖salecan和N,N,N-三甲基壳聚糖（TMC）的自组装轻松制备。两种多糖之间的静电相互作用是络合过程的驱动力，并已通过 FTIR、XRD、XPS 和 TGA 得到证明。通过控制salecan/TMC比例可以很好地调节水凝胶的溶胀能力、形态和流变性能。绿茶多酚 (GTP) 被有效封装到 PEC 水凝胶中并以持续的方式释放。模拟肠液（SIF）中GTP释放量显着高于模拟胃液（SGF）。增加salecan/TMC比率也显着增加GTP释放量。 SGF 中获得的释放指数 n 表明存在 Fickian 扩散，而 SIF 中发生了异常传输。该释放机构与Ritger-Peppas模型非常吻合。总而言之，这些 PEC 水凝胶可能是肠道靶向营养输送的合适载体。
In this study, we have developed a novel polyelectrolyte complex (PEC) hydrogel that could be easily prepared by self-assembly of two food-grade polysaccharides salecan and N,N,N-trimethyl chitosan (TMC). The electrostatic interactions between two polysaccharides were driving force in complexation processes and have been demonstrated by FTIR, XRD, XPS and TGA. The swelling capacity, morphology and rheological property of the hydrogels could be well tuned by controlling salecan/TMC ratio. Green tea polyphenols (GTP) was efficiently encapsulated into PEC hydrogels and liberated in a sustained pattern. The amount of GTP released in simulated intestinal fluid (SIF) was significantly higher than simulated gastric fluid (SGF). Increasing salecan/TMC ratio also markedly enhanced GTP release amount. Release exponent n obtained in SGF indicated a Fickian diffusion, while in SIF an anomalous transport occurred. The release mechanism was well-fitted with Ritger-Peppas model. Taken together, these PEC hydrogels could be suitable carriers for intestinal targeted nutrient delivery.