Visceral obesity may affect oncologic outcome in patients with colorectal cancer
Visceral obesity may affect oncologic outcome in patients with colorectal cancer
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DOI：
10.1245/s10434-008-9891-4
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发表时间：
2008-07-01
影响因子：
3.7
通讯作者：
Choi, Sang-Kyung
中科院分区：
文献类型：
--
作者：
Moon, Hyeong-Gon;Ju, Young-Tae;Choi, Sang-Kyung
目的：肥胖与结直肠癌及其他代谢并发症的发生密切相关。我们调查了161例可切除结直肠癌患者内脏肥胖和体重指数（BMI）的预后意义。根据术前患者计算机断层扫描的数字图像测量内脏脂肪面积（VFA）与皮下脂肪面积（SFA）的比值，根据内脏脂肪比例的高低将患者分为VFA/SFA比值高和低的两组，结果：与正常体重组相比，超重组的累积无病生存率下降（P = 0.064）。VFA/SFA比值高（> 50 μ l）的患者累积无病生存率显著低于VFA/SFA比值低的患者（P = 0.008）。BMI和内脏肥胖对患者的总生存率没有影响。结论：内脏肥胖增加是可切除结直肠癌患者无病生存率的一个重要预测因素。内脏肥胖的预后意义应进一步确定在一个更大的患者集。
Purpose: Obesity is closely related to the development of colorectal cancer as well as other metabolic complications. We investigated the prognostic significance of visceral obesity and body mass index (BMI) in 161 resectable colorectal cancer patients.Methods: Ratios of visceral fat area (VFA) to subcutaneous fat area (SFA) were measured from the digital images of patients' computed tomography taken before the surgery, and patients were divided into those with high and those with low VFA/SFA ratio according to the degree of proportional visceral adiposity, and into an overweight and a normal-weight group according to their preoperative BMI.Results: The overweight group showed a borderline decrease in cumulative disease-free survival compared to the normal-weight group (P = 0.064). Patients with high VFA/SFA ratio (more than 50 percentiles) had significantly lower cumulative disease-free survival rate compared to patients with low VFA/SFA ratio (P = 0.008). BMI and visceral adiposity showed no influence on overall survival of patients.Conclusion: Increased visceral adiposity was a significant predictor of disease-free survival in patients with resectable colorectal cancer. The prognostic significance of visceral adiposity should further be determined in a larger set of patients.