REMOTE-SITE STIMULATION OF INFLUENZA ANTIBODIES IN MONKEYS FOLLOWING INTESTINAL STIMULATION
REMOTE-SITE STIMULATION OF INFLUENZA ANTIBODIES IN MONKEYS FOLLOWING INTESTINAL STIMULATION
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DOI：
10.1016/0165-2478(86)90084-2
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发表时间：
1986-03-01
影响因子：
4.4
通讯作者：
TISCHNER, H
中科院分区：
文献类型：
--
作者：
BERGMANN, KC;WALDMAN, RH;TISCHNER, H
用灭活流感疫苗经口免疫10只猕猴，激发鼻分泌物和唾液中的抗体。免疫前，猴血清或分泌物中未检测到流感病毒血凝素或神经氨酸酶抗体。口服免疫（12天内6次，共0.6 mg血凝素（HA）和240个神经氨酸酶单位）使用食管内插管诱导分泌抗体的抗原，但没有血清抗体。分别有6只和8只猴子在鼻分泌物和唾液中与HA抗体发生反应，而神经氨酸酶抗体发生在所有10只猴子的鼻分泌物和9只猴子的唾液中。这些结果支持了猴的共同粘膜免疫系统的概念。
Antibodies in nasal secretions and saliva were stimulated in 10 monkeys (Macacus rhesus) which had been immunized orally with a killed influenza vaccine. Prior to immunization, monkeys had no detectable antibody to influenza virus hemagglutinin or neuraminidase in sera or secretions. Oral immunization (6 times within 12 days, total of 0.6 mg hemagglutinin (HA) and 240 neuraminidase units) using intraesophageal intubation induced secretory antibodies to both antigens, but no serum antibody. Six and 8 monkeys reacted with HA-antibodies in nasal secretions and saliva, respectively, whereas neuraminidase antibodies occurred in nasal secretions of all 10 and in the saliva of 9 animals. The results support the concept of a common mucosal immune system in monkeys.