Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine.
Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine.
复制标题
褪黑激素和乙酰左旋肉碱逆转大脑衰老的生化和行为参数。
DOI：
10.1016/s0006-8993(02)03551-5
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发表时间：
2002
期刊：
影响因子：
2.9
通讯作者：
Bondy,SC
中科院分区：
文献类型：
--
作者：
Sharman,EdwardH;Vaziri,NosratolaD;Ni,Zhenmin;Sharman,KaizhiG;Bondy,SC
饮食补充的潜在效用，以防止一些氧化和炎症变化发生在大脑中的年龄，已被研究。27个月龄雄性B6C3F1小鼠大脑皮层中一氧化氮合酶1(EC1.14.13.39)(NNOS)和多肽硝基酪氨酸水平较年轻(4个月龄)小鼠高。25个月龄小鼠在饮水中加入300 mg/L乙酰L肉碱8周后，这些水平完全恢复到年轻动物的水平。当老年动物接受基础日粮中添加200ppm褪黑素时，发现部分恢复。在这些治疗后，nNOS的信使RNA水平没有变化，这意味着nNOS活性的翻译调节。表明探索性行为的行为指数在老年动物中也受到抑制。饮食中补充褪黑激素或乙酰L肉碱部分逆转了这些变化。这些发现表明，膳食补充剂不仅不能阻止，而且确实可以逆转一些与年龄相关的皮质氧化和炎症事件标志物的增加。
The potential utility of dietary supplementation in order to prevent some of the oxidative and inflammatory changes occurring in the brain with age, has been studied. The cerebral cortex of 27-month-old male B6C3F1 mice had elevated levels of nitric oxide synthase 1 (EC 1.14.13.39) (nNOS) and peptide nitrotyrosine relative to cortices of younger (4-month-old) animals. After 25-month-old mice received basal diet together with 300 mg/l acetyl l-carnitine in the drinking water for 8 weeks, these levels were fully restored to those found in younger animals. A partial restoration was found when old animals received basal diet supplemented with 200 ppm melatonin in the diet. Levels of mRNA (messenger RNA) for nNOS were unchanged following these treatments implying translational regulation of nNOS activity. Behavioral indices indicative of exploratory behavior were also depressed in aged animals. Dietary supplementation with melatonin or acetyl l-carnitine partially reversed these changes. These findings suggest that dietary supplementation cannot merely arrest but indeed reverse some age-related increases in markers of oxidative and inflammatory events occurring with the cortex.