RESETTING OF THE RAT CIRCADIAN CLOCK AFTER A SHIFT IN THE LIGHT DARK CYCLE DEPENDS ON THE PHOTOPERIOD
RESETTING OF THE RAT CIRCADIAN CLOCK AFTER A SHIFT IN THE LIGHT DARK CYCLE DEPENDS ON THE PHOTOPERIOD
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DOI：
10.1016/0168-0102(92)90095-t
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发表时间：
1992-03-01
影响因子：
2.9
通讯作者：
ILLNEROVA, H
中科院分区：
文献类型：
--
作者：
HUMLOVA, M;ILLNEROVA, H
从大鼠松果体N-乙酰转移酶（NAT）的节奏，这是由下丘脑的视交叉上核的起搏器控制的昼夜节律钟的光/暗（LD）周期的变化进行了评估。在LD周期中延迟8小时的再夹带在每天18小时光照和6小时黑暗（LD 18：6）的制度下维持的大鼠中需要3天以上，而在LD 12：12下维持的大鼠中在3天内完成。在LD 18：6下，通过NAT节律振幅在5小时、3小时甚至仅仅2小时提前移位后的短暂减小或几乎消失，再夹带到LD周期中的提前，而在LD 12：12下，即使在5小时提前移位后也没有发生这种减小。总之，数据表明，在LD周期中的移位之后的生物钟的重置取决于光周期。
Adjustment of the circadian clock to shifts in the light/dark (LD) cycle was assessed from the rat pineal N-acetyltransferase (NAT) rhythm which is controlled by a pacemaker in the suprachiasmatic nucleus of the hypothalamus. Re-entrainment to an 8-h delay in the LD cycle took more than 3 days in rats maintained under a regime with 18 h of light and 6 h of darkness per day (LD 18:6) whereas it was completed within 3 days in those maintained under LD 12:12. Re-entrainment to an advance in the LD cycle proceeded through a transient diminution or almost disappearance of the NAT rhythm amplitude following a 5-h, 3-h and even a mere 2-h advance shift under LD 18:6, whereas no such diminution occurred under LD 12:12 even after a 5-h advance shift. Altogether, the data indicate that resetting of the circadian clock after shifts in the LD cycle depends on the photoperiod.