Longitudinal functional magnetic resonance imaging in animal models.
Longitudinal functional magnetic resonance imaging in animal models.
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DOI：
10.1007/978-1-61737-992-5_14
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Stefanovic B
中科院分区：
文献类型：
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作者：
Silva AC;Liu JV;Hirano Y;Leoni RF;Merkle H;Mackel JB;Zhang XF;Nascimento GC;Stefanovic B
功能性磁共振成像（fMRI）在促进我们对大脑生理和功能的理解方面发挥了重要作用。功能磁共振成像技术目前在神经科学研究以及转化和临床研究中得到广泛应用。在功能磁共振成像研究中使用动物模型在帮助阐明脑血流调节机制和探索基本神经科学问题（如感知、行为和认知机制）方面具有重要意义。由于动物天生不适应，迄今为止进行的大多数fMRI都需要使用麻醉，这干扰了大脑功能，损害了结果对我们对人类大脑功能的理解的可解释性和适用性。另一种不需要麻醉的方法是训练动物在数据采集过程中忍受身体约束。在目前的工作中，我们回顾了从动物模型中获取功能磁共振成像数据的两种不同方法，特别关注从同一受试者中获取纵向数据。
Functional magnetic resonance imaging (fMRI) has had an essential role in furthering our understanding of brain physiology and function. fMRI techniques are nowadays widely applied in neuroscience research, as well as in translational and clinical studies. The use of animal models in fMRI studies has been fundamental in helping elucidate the mechanisms of cerebral blood flow regulation, and in the exploration of basic neuroscience questions, such as the mechanisms of perception, behavior, and cognition. Because animals are inherently noncompliant, most fMRI performed to date have required the use of anesthesia, which interferes with brain function and compromises interpretability and applicability of results to our understanding of human brain function. An alternative approach that eliminates the need for anesthesia involves training the animal to tolerate physical restraint during the data acquisition. In the present work we review these two different approaches to obtaining fMRI data from animal models, with a specific focus on the acquisition of longitudinal data from the same subjects.