Effect of respiratory hospitalization during pregnancy on infant outcomes
Effect of respiratory hospitalization during pregnancy on infant outcomes
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DOI：
10.1016/j.ajog.2011.04.031
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发表时间：
2011-06-01
影响因子：
9.8
通讯作者：
MacDonald, Noni E.
中科院分区：
文献类型：
--
作者：
McNeil, Shelly A.;Dodds, Linda A.;MacDonald, Noni E.
本研究的目的是确定是否产妇住院治疗的相关条件在流感季节的结果增加新生儿发病率的风险。在新斯科舍省（1990-2002年）对所有单胎活产婴儿进行了一项为期13年的基于人群的队列研究，比较了在流感季节任何时间因呼吸道疾病住院和未住院的妇女之间的新生儿结局。进行逻辑回归分析以检查婴儿结局并估计相对风险和95%置信区间。母亲在流感季节因呼吸道疾病住院治疗，在怀孕期间的任何时候所生的婴儿更有可能小于胎龄（15.3% vs 9.7%;校正相对危险度，1.66; 95%置信区间，1.11-2.49）和平均出生体重较低（3348.5 +/- 498.2 g vs 3531.3 +/- 504.1 g; β评分，-86.67; P <0.009）比妊娠期间未因流感季节呼吸道疾病住院的妇女所生的婴儿低。我们在高资源环境下出生的单胎婴儿队列中的研究结果支持了孟加拉国的研究结果，该研究结果表明，未受流感疫苗保护的母亲所生婴儿中，小于胎龄儿数量增加，平均出生体重较低。
The purpose of this study was to determine whether maternal hospitalization for a respiratory-related condition during influenza season results in an increased risk of neonatal morbidity. With the use of a 13-year population-based cohort study of all singleton live births in Nova Scotia (1990-2002), neonatal outcomes were compared between women with and without hospital admission for respiratory illness during influenza season at any time in pregnancy. Logistic regression analyses were performed to examine infant outcomes and to estimate relative risks and 95% confidence intervals. Infants who were born to mothers who had been hospitalized for respiratory illness during influenza season at any time during pregnancy were more likely to be small for gestational age (15.3% vs 9.7%; adjusted relative risk, 1.66; 95% confidence interval, 1.11-2.49) and to have lower mean birthweight (3348.5 +/- 498.2 g vs 3531.3 +/- 504.1 g; beta score, -86.67; P < .009) than were infants who were born to women without an influenza-season respiratory hospitalization during pregnancy. Our findings in a cohort of singleton infants who were born in a high-resource setting support the findings that were described in Bangladesh that demonstrated an increased number of small-for-gestational-age infants and a lower mean birthweight among babies who were born to mothers who were not protected by influenza vaccine.