Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea
Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea
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DOI：
10.1016/j.jinf.2006.11.008
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发表时间：
2007-06-01
影响因子：
28.2
通讯作者：
Park, C. K.
中科院分区：
文献类型：
--
作者：
Chung, D. R.;Lee, S. S.;Park, C. K.
目的：肺炎克雷伯杆菌所引起的侵袭性肝脓疡在台湾的高发生率，与此疾病在西方国家的罕见率形成对比，引起了特别的兴趣。其他亚洲国家的详细报告很少。目的了解克雷伯氏菌的流行病学现状。肺炎克雷伯氏菌肝脓肿，并确定K血清型分布在韩国。肺炎菌株引起肝脓肿，我们进行了一项全国性的前瞻性研究。分析病因及临床特点。K.肺炎分离株根据K抗原进行血清分型。结果：在前瞻性收集的371例肝脓肿病例中，290例（78.2%）由克雷伯菌引起。肺炎。最K。肺炎性肝脓肿为单菌性。糖尿病是最常见的基础疾病（39.9%）。经常观察到远处转移性感染（8.7%）。magA PCR检测结果表明，160株K.结论：肺炎克雷伯氏菌属K1血清型。肺炎克雷伯氏菌已成为韩国肝脓肿的主要病原体，这些新出现的感染似乎可归因于侵袭性肺炎克雷伯氏菌。pneumoniae菌株，具有荚膜K1血清型。(C)2006年，英国传染病协会。由爱思唯尔有限公司出版。保留所有权利。
Objectives: The high incidence of invasive Liver abscess caused by Klebsiella pneumoniae in Taiwan, contrasted with the rareness of this disease in Western countries, has aroused special interest. There have been few detailed reports from other Asian countries. To investigate a current epidemiology of K. pneumoniae liver abscess in Korea and to determine K serotype distribution in K. pneumoniae strains causing liver abscess, we performed a nationwide prospective study.Methods: Community-acquired, culture-proven liver abscess cases were enrolled between 2004 and 2005. Etiologies and clinical features were analyzed. K. pneumoniae isolates were serotyped according to K antigen. Meta-analysis was done to determine the time trend of the etiologies of liver abscess in Korea.Results: Out of 371 cases collected prospectively, 290 (78.2%) were caused by K. pneumoniae. Most K. pneumoniae liver abscesses were monomicrobial. Diabetes mellitus was the most common underlying disease (39.9%). Distant metastatic infections were frequently observed (8.7%). magA PCR revealed that 95 (59.4%) out of 160 K. pneumoniae isolates belonged to the K1 serotype.Conclusions: Our study indicates that K. pneumoniae has emerged as a major etiologic agent of liver abscess in Korea, and these emerging infections seem to be attributable to invasive K. pneumoniae strains with capsular K1 serotype. (C) 2006 The British Infection Society. Published by Elsevier Ltd. All rights reserved.