Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa
Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa
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DOI：
10.1073/pnas.0901983106
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发表时间：
2009-04-21
影响因子：
11.1
通讯作者：
Quinn, Thomas C.
中科院分区：
文献类型：
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作者：
Redd, Andrew D.;Dabitao, Djeneba;Quinn, Thomas C.
来自美国的报告表明，在慢性和晚期HIV-1感染中可能发现肠道微生物易位标志物升高，并与免疫激活增加有关。然而，这种现象在非洲HIV-1疾病中的作用尚不清楚。本研究在乌干达Rakai的一组HIV-1疾病进展率不同的人群中检查了微生物易位和循环炎性细胞因子反应之间的纵向关系。在HIV-1疾病进展过程中，微生物易位的多种标志物（脂多糖、内毒素抗体和sCD 14）没有显著变化。此外，在整个疾病进展过程中，循环免疫反应性细胞因子水平降低或几乎保持不变。这些数据表明，微生物易位及其随后的炎症免疫反应与非洲的HIV-1疾病进展没有因果关系。
Reports from the United States have demonstrated that elevated markers of microbial translocation from the gut may be found in chronic and advanced HIV-1 infection and are associated with an increase in immune activation. However, this phenomenon's role in HIV-1 disease in Africa is unknown. This study examined the longitudinal relationship between microbial translocation and circulating inflammatory cytokine responses in a cohort of people with varying rates of HIV-1 disease progression in Rakai, Uganda. Multiple markers for microbial translocation (lipopolysaccharide, endotoxin antibody, and sCD14) did not change significantly during HIV-1 disease progression. Moreover, circulating immunoreactive cytokine levels either decreased or remained virtually unchanged throughout disease progression. These data suggest that microbial translocation and its subsequent inflammatory immune response do not have a causal relationship with HIV-1 disease progression in Africa.