Cognitive effects of "older" anticonvulsants in children with epilepsy: a review and critique of the literature.
Cognitive effects of "older" anticonvulsants in children with epilepsy: a review and critique of the literature.
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DOI：
10.5863/1551-6776-8.2.115
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发表时间：
2003-04-01
期刊：
影响因子：
--
通讯作者：
Ries, Michele
中科院分区：
文献类型：
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作者：
Ries, Michele
癫痫性疾病儿童的认知能力下降是由几个因素引起的，其中一个是抗惊厥药物和总抗惊厥药物暴露的选择。这篇论文回顾了关于“老”抗惊厥药物（即，苯巴比妥，苯妥英，卡马西平和丙戊酸）作为单一疗法的认知影响的研究。许多认知困难，如智力下降、轻度记忆丧失、视觉运动障碍和精神运动减慢都与这些药物有关。本综述中包括的每项研究都是根据研究设计的适当性和读者得出与所研究的抗惊厥药相关的认知效应的明确结论的能力进行评估的。这篇评论也包括了对困扰这一文献体系的无数方法论难题的概述。从现有文献中得出结论，并提出了未来的研究方向。
Cognitive decline in children with seizure disorders is due to several factors, one being the choice of anticonvulsant and total anticonvulsant exposure. This paper reviews research investigating cognitive effects associated with "older" anticonvulsant medications (i.e., phenobarbital, phenytoin, carbamazepine, and valproate) prescribed as monotherapy. A number of cognitive difficulties such as intellectual decline, mild memory loss, visual-motor impairment, and psychomotor slowing have been associated with these medications. Each study included in this review is assessed in terms of the appropriateness of study design and ability of the reader to draw clear conclusions about the cognitive effects associated with the anticonvulsant under investigation. The review also includes a synopsis of the myriad of methodological difficulties that plague this body of literature. Conclusions that can be drawn from the existing literature are delineated, and future directions for research are suggested.