Oral vaccination with alginate microsphere systems
Oral vaccination with alginate microsphere systems
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DOI：
10.1016/0168-3659(95)00155-7
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发表时间：
1996-05-01
影响因子：
10.8
通讯作者：
Park, K
中科院分区：
文献类型：
--
作者：
Bowersock, TL;HogenEsch, H;Park, K
口服疫苗是一种简单、有效的诱导粘膜表面免疫力的方法。口服疫苗发展缓慢主要是由于缺乏合适的递送系统。我们已经使用水凝胶微球通过口服向多种动物物种输送各种疫苗。使用海藻酸盐微球口服疫苗可在小鼠、兔子和牛的粘膜表面产生分泌型 IgA (sIgA)。鸡口服疫苗会导致迟发型超敏反应增加，这是一种细胞介导的免疫反应，表明对疫苗有积极反应。我们的研究清楚地表明海藻酸盐微球对于口服疫苗是有效的。
Oral vaccination is a simple, efficient way of inducing immunity at mucosal surfaces. The slow development of oral vaccines has been mainly due to the lack of suitable delivery systems. We have used hydrogel microspheres to deliver various vaccines to several animal species by oral administration. Oral delivery of vaccines using alginate microspheres elicited the production of secretory IgA (sIgA) at the mucosal surfaces in mice, rabbits, and cattle. Oral vaccination of chicken resulted in an increased delayed-type hypersensitivity, a cell-mediated immune response, indicating a positive response to the vaccine. Our studies have clearly shown that alginate microspheres are effective for the oral administration of vaccines.