The Concise Guide to PHARMACOLOGY 2015/16: Transporters.
The Concise Guide to PHARMACOLOGY 2015/16: Transporters.
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DOI：
10.1111/bph.13355
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发表时间：
2015-12
影响因子：
7.3
通讯作者：
CGTP Collaborators
中科院分区：
文献类型：
--
作者：
Alexander SP;Kelly E;Marrion N;Peters JA;Benson HE;Faccenda E;Pawson AJ;Sharman JL;Southan C;Davies JA;CGTP Collaborators
《药理学简明指南2015/16》简要概述了超过1750种人类药物靶点及其药理学的关键特性，并提供了药物靶点及其配体的开放知识库链接（www.guidetopharmacology.org），该知识库提供了更详细的靶点和配体特性视图。完整的内容可以在http://onlinelibrary.wiley.com/doi/10.1111/bph.13355/full上找到。G蛋白偶联受体是《指南》划分的八个主要药理学靶点之一，其他靶点包括：G蛋白偶联受体、配体门控离子通道、电压门控离子通道、其他离子通道、核激素受体、催化受体和转运体。这些都提出了命名指导和总结信息的最佳可用药理学工具，以及关键的参考文献和建议，以进一步阅读。《简明指南》以景观格式出版，以便比较相关目标。它是2015年末材料的浓缩版本，在网站www.guidetopharmacology.org上提供了更详细和不断更新的内容，取代了以前的受体和通道指南和2013/14年药理学简明指南中提供的数据。它与NC - IUPHAR一起制作，并在适当的情况下为人类药物靶标提供官方IUPHAR分类和命名。它整合了以前在IUPHAR - DB和GRAC中单独策划和显示的信息，并提供了一个永久的，可引用的，时间点记录，将在数据库更新中幸存下来。
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13355/full. G protein‐coupled receptors are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ligand‐gated ion channels, voltage‐gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC‐IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR‐DB and GRAC and provides a permanent, citable, point‐in‐time record that will survive database updates.