Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior
Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior
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DOI：
10.1002/adma.201504995
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发表时间：
2016-02-17
影响因子：
29.4
通讯作者：
Ogaki, Ryosuke
中科院分区：
文献类型：
--
作者：
Amin, Yacoub Y. I.;Runager, Kasper;Ogaki, Ryosuke
报道了一种新的组合生物分子纳米图案化方法，其中多个生物分子配体可以在单个表面上以多个纳米尺度图案化。通过平行筛选人牙髓干细胞（hDPSC）群体在64种纳米图案化细胞外基质（ECM）蛋白组合上的粘附行为来证明组合平台对细胞生物学应用的适用性。
A novel combinatorial biomolecular nanopatterning method is reported, in which multiple biomolecular ligands can be patterned in multiple nanoscale dimensions on a single surface. The applicability of the combinatorial platform toward cell-biology applications is demonstrated by screening the adhesion behavior of a population of human dental pulp stem cell (hDPSC) on 64 combinations of nanopatterned extracellular matrix (ECM) proteins in parallel.