Conducting polymers for neural interfaces: Challenges in developing an effective long-term implant
Conducting polymers for neural interfaces: Challenges in developing an effective long-term implant
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DOI：
10.1016/j.biomaterials.2008.04.047
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发表时间：
2008-08-01
期刊：
影响因子：
14
通讯作者：
Poole-Warren, Laura A.
中科院分区：
文献类型：
--
作者：
Green, Rylie A.;Lovell, Nigel H.;Poole-Warren, Laura A.
用于有源植入式装置的金属电极材料通常具有较差的长期刺激和记录性能。利用导电聚合物涂层对这些材料进行改性是改善神经组织-电极界面和增加这些植入物有效寿命的一种方法。理想情况下，神经界面在可兴奋组织和电极之间保持密切接触，以维持信号质量和神经细胞的激活。目前对导电聚合物涂层的研究成果有可能通过增加电极表面积和粗糙度来增强组织与材料的接触，并允许向神经细胞传递生物活性信号。然而，导电聚合物面临的挑战包括较差的电活性稳定性和机械性能，以及对生物活性分子的移动性、浓度和表现的控制。生物包裹体对聚合物性能及其在神经义肢中的持续性能的影响需要进一步了解，未来的研究旨在控制和优化膜的长期性能。优化电极界面需要在期望的电学、机械、化学和生物特性之间进行权衡。(c) 2008 Elsevier Ltd.版权所有。
Metal electrode materials used in active implantable devices are often associated with poor long-term stimulation and recording performance. Modification of these materials with conducting polymer coatings has been suggested as an approach for improving the neural tissue-electrode interface and increasing the effective lifetime of these implants. Neural interfaces ideally have intimate contact between the excitable tissue and the electrode to maintain signal quality and activation of neural cells. The outcomes of current research into conducting polymers as coatings has potential to enhance this tissue-material contact by increasing the electrode surface area and roughness as well as allowing delivery of bioactive signals to neural cells. However, challenges facing conducting polymers include poor electroactive stability and mechanical properties as well as control of the mobility, concentration and presentation of bioactive molecules. The impact of biological inclusions on polymer properties and their ongoing performance in neural prosthetics requires a greater understanding with future research aimed at controlling and optimising film characteristics for long-term performance. Optimising the electrode interface will require a trade-off between desired electrical, mechanical, chemical and biological properties. (c) 2008 Elsevier Ltd. All rights reserved.