The central projections of the monkey tooth pulp afferent neurons.
The central projections of the monkey tooth pulp afferent neurons.
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DOI：
10.3109/08990229309028833
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发表时间：
1993
影响因子：
0.9
通讯作者：
M. Takemura;Y. Nagase;Atsushi Yoshida;Kouichi Yasuda;Seiichiro Kitamura;Y. Shigenaga;Shozo Matano
中科院分区：
文献类型：
--
作者：
M. Takemura;Y. Nagase;Atsushi Yoshida;Kouichi Yasuda;Seiichiro Kitamura;Y. Shigenaga;Shozo Matano
辣根过氧化物酶结合小麦胚芽凝集素（HRP：WGA）包埋在低过敏性聚丙烯酰胺凝胶的跨神经节运输被用来研究终止的初级传入，支配上，下牙髓内的三叉神经感觉核复合体（TSNC）的猴子的模式。HRP：WGA注射也被用于下切牙和磨牙，以检查牙髓传入投射的地形布置。HRP标记的神经支配下牙和上牙的牙髓传入纤维向同侧投射至主核（Vp）的吻侧背侧亚核（Vpd）和尾侧腹侧亚核（Vpv）;吻侧背内侧核（Vo. r）和背内侧（Vo.dm）口核（Vo）的亚部;极间核（Vi）的背内侧亚部;尾侧核（Vc）的I~II和/或V层位于其吻侧水平。上下牙髓传入纤维的HRP标记终末从Vp的中层到Vc的吻端形成一个吻尾柱。Vp和Vo中的标记相当密集，但在Vpd-Vpv转变处末端列被中断。Vi和Vc的标记密度远低于吻侧核，终末柱经常中断。TSNC中上下牙齿的代表性以躯体位置的方式组织，从一个细分到下一个细分，尽管它们的终端区域在Vpd内重叠。上、下牙分别以Vpv、Vo. r、www.example.com、Vi和Vc表示，顺序为腹背侧、背腹侧、侧内侧、侧内侧和侧内侧。地形安排也注意到从下切牙和磨牙的牙髓传入的预测：在Vpv，Vo. r，www.example.com，Vi和Vc的下切牙和磨牙的表示被组织在一个lateromedial，dorsoventral，ventrodorsal，ventrodorsal和lateromedial序列，分别。目前的研究结果表明，稀疏的预测从牙髓传入的猴子的Vc是在良好的对应关系的临床报告，三叉神经束切断术只是喙的obex没有显着影响患者的牙痛的感觉。此外，本研究表明，牙髓传入的投射模式-其中包括终止网站，核之间的终端密度，地形安排-不同的动物物种。
Transganglionic transport of horseradish peroxidase conjugated to wheatgerm agglutinin (HRP:WGA) entrapped in hypoallergenic polyacrylamide gel was used to study the patterns of termination of primary afferents that innervate the upper and lower tooth pulps within the trigeminal sensory nuclear complex (TSNC) of the monkey. HRP:WGA injections were also made into the lower incisors and molars, in order to examine the topographic arrangement of pulpal afferent projections. HRP-labeled pulpal afferents innervating lower and upper teeth projected ipsilaterally to the rostral subnucleus dorsalis (Vpd) and caudal subnucleus ventralis (Vpv) of the nucleus principalis (Vp); the rostrodorsomedial (Vo.r) and dorsomedial (Vo.dm) subdivisions of the nucleus oralis (Vo); the dorsomedial subdivision of the nucleus interpolaris (Vi); and laminae I-II and/or V of the nucleus caudalis (Vc) at its rostralmost level. The HRP-labeled terminals from upper and lower pulpal afferents formed a rostrocaudal column from the midlevel of Vp to the rostral tip of Vc. The label in Vp and Vo was considerably dense, but the column of terminals was interrupted at the Vpd-Vpv transition. The label in Vi and Vc was much less dense compared to that in the rostral nuclei, and the column of terminals was interrupted frequently. The representation of the upper and lower teeth in TSNC was organized in a somatotopic fashion that varied from one subdivision to the next, though their terminal zones overlapped within Vpd. The upper and lower teeth were represented in Vpv, Vo.r, Vo.dm, Vi, and Vc in a ventrodorsal, dorsoventral, lateromedial, lateromedial, and lateromedial sequence, respectively. Topographic arrangement was also noticed for the projections of pulpal afferents from the lower incisors and molars: The representations of the lower incisors and molars in Vpv, Vo.r, Vo.dm, Vi, and Vc were organized in a lateromedial, dorsoventral, ventrodorsal, ventrodorsal, and lateromedial sequence, respectively. The present results indicating sparse projections from pulpal afferents in the monkey's Vc are in good correspondence with a clinical report that trigeminal tractotomy just rostral to the obex has no significant effect on dental pain perception in patients. Furthermore, the present study indicates that projection patterns of pulpal afferents--which include the termination sites, the density of terminations between nuclei, and topographic arrangement--differ among animal species.