Mild Parkinsonian Signs, Energy Decline, and Striatal Volume in Community-Dwelling Older Adults.
Mild Parkinsonian Signs, Energy Decline, and Striatal Volume in Community-Dwelling Older Adults.
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社区居住老年人的轻度帕金森症状、能量下降和纹状体体积。
DOI：
10.1093/gerona/glab150
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Rosano,Caterina
中科院分区：
文献类型：
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作者：
Tian,Qu;Ehrenkranz,Rebecca;Rosso,AndreaL;Glynn,NancyW;Chahine,LanaM;Hengenius,James;Zhu,Xiaonan;Rosano,Caterina
背景轻度帕金森综合征（MPS）在老年人中非常普遍，可预测残疾。目前尚不清楚能量下降（活动性残疾的预测因子）是否也与MPS相关。我们假设患有MPS的患者自我报告的能量水平（SEL）下降幅度大于没有MPS的患者，并且SEL下降和MPS共享神经基质。（83 ± 3岁，39%黑人，58%女性），具有神经影像学数据，2006-2008年通过统一帕金森病评定量表进行MPS评价，自1999-2000年以来，SEL ≥3次。通过线性混合模型计算个体SEL斜率。使用逻辑回归模型测试了SEL斜率与MPS的关联。SEL斜率与纹状体体积、感觉运动和认知区域的关联使用校正标准化总灰质体积的线性回归模型进行检查。模型进行了调整基线SEL，流动性，人口统计学，和comorbidity.ResultsCompared那些没有MPS（n= 165），那些与MPS（n= 128）有37%以上SEL下降在过去的8年（p= 0.001）。SEL下降越大，右侧纹状体体积越小（校正标准化β = 0.126，p = 0.029）。SEL下降与其他地区的销量无关。校正右侧纹状体体积后，SEL下降与MPS的相关性仍然相似（校正比值比= 2.03，95%CI：1.16-3.54）。纹状体萎缩可能对能量下降很重要，但不能解释与MPS的相关性。
BackgroundMild parkinsonian signs (MPS), highly prevalent in older adults, predict disability. It is unknown whether energy decline, a predictor of mobility disability, is also associated with MPS. We hypothesized that those with MPS had greater decline in self-reported energy level (SEL) than those without MPS, and that SEL decline and MPS share neural substrates.MethodUsing data from the Health, Aging and Body Composition Study, we analyzed 293 Parkinson’s disease-free participants (83 ± 3 years old, 39% Black, 58% women) with neuroimaging data, MPS evaluation by Unified Parkinson Disease Rating Scale in 2006–2008, and ≥3 measures of SEL since 1999–2000. Individual SEL slopes were computed via linear mixed models. Associations of SEL slopes with MPS were tested using logistic regression models. Associations of SEL slope with volume of striatum, sensorimotor, and cognitive regions were examined using linear regression models adjusted for normalized total gray matter volume. Models were adjusted for baseline SEL, mobility, demographics, and comorbidities.ResultsCompared to those without MPS (n= 165), those with MPS (n= 128) had 37% greater SEL decline in the prior 8 years (p= .001). Greater SEL decline was associated with smaller right striatal volume (adjusted standardized β = 0.126,p= .029). SEL decline was not associated with volumes in other regions. The association of SEL decline with MPS remained similar after adjustment for right striatal volume (adjusted odds ratio = 2.03, 95% CI: 1.16–3.54).ConclusionSEL decline may be faster in those with MPS. Striatal atrophy may be important for declining energy but does not explain the association with MPS.