Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.
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DOI：
10.1158/2159-8290.cd-16-0615
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发表时间：
2016-12
期刊：
影响因子：
28.2
通讯作者：
Longo V
中科院分区：
文献类型：
--
作者：
Vernieri C;Casola S;Foiani M;Pietrantonio F;de Braud F;Longo V
大多数肿瘤显示癌基因驱动的几种代谢途径的重编程，这对维持其生长和增殖至关重要。近年来，针对失调的肿瘤代谢的饮食和药理学方法开始被考虑用于临床应用。饮食干预利用营养限制条件的能力来发挥广泛的生物效应，保护正常细胞，器官和系统，同时使各种癌细胞对细胞毒性疗法敏感。另一方面，靶向关键代谢途径的酶或代谢物的药物可能具有高度特异性和有效性，但必须与可能迅速适应的反应性肿瘤相匹配。在这篇综述中，我们说明了饮食和药物治疗对肿瘤生长，增殖和代谢的影响如何不同，并讨论了支持或反对它们的临床前和临床证据。我们还指出，在适当的情况下，如何优化未来的研究代谢疗法的基础上，肿瘤和患者相关的特点。
Most tumors display oncogene-driven reprogramming of several metabolic pathways, which are crucial to sustain their growth and proliferation. In recent years, both dietary and pharmacological approaches that target deregulated tumor metabolism are beginning to be considered for clinical applications. Dietary interventions exploit the ability of nutrient-restricted conditions to exert broad biological effects, protecting normal cells, organs and systems, while sensitizing a wide variety of cancer cells to cytotoxic therapies. On the other hand, drugs targeting enzymes or metabolites of crucial metabolic pathways can be highly specific and effective, but must be matched with a responsive tumor, which might rapidly adapt. In this Review, we illustrate how dietary and pharmacological therapies differ in their effect on tumor growth, proliferation and metabolism, and discuss the available preclinical and clinical evidence in favor or against each of them. We also indicate, when appropriate, how to optimize future investigations on metabolic therapies on the basis of tumor- and patient-related characteristics.