Maintenance of gut barrier integrity after injury: Trust your gut microRNAs.
Maintenance of gut barrier integrity after injury: Trust your gut microRNAs.
复制标题
DOI：
10.1002/jlb.3ru0120-090rr
复制
发表时间：
2021-11
影响因子：
5.5
通讯作者：
Choudhry MA
中科院分区：
文献类型：
--
作者：
Morris NL;Choudhry MA
胃肠道 (GI) 是一个高度动态的结构，对于消化、营养吸收和提供防止肠道细菌移位的界面至关重要。为了维持屏障功能，肠道利用许多防御机制，包括增殖、凋亡和顶端连接复合物。由于损伤或疾病而破坏这些参数中的任何一个都可能对肠道屏障功能和稳态产生负面影响，导致肠道炎症、通透性、细菌失调和组织损伤增加。 MicroRNA 是小的非编码 RNA 序列，是正常细胞稳态的主要调节因子。这些调节分子影响细胞信号传导途径，并可能作为在胃肠道相关病理状况、乙醇暴露或烧伤等创伤后提供肠道屏障完整性受损机制的候选分子。 MicroRNA 影响细胞凋亡、增殖、顶端连接复合物表达、炎症和微生物组。由于其广泛的功能关联，microRNA 的表达改变与许多病理状况相关。本综述探讨了 microRNA 在调节肠道屏障完整性中的作用。审查的研究表明，microRNA 在很大程度上影响肠道屏障功能，并提供了乙醇和烧伤后观察到的不良反应背后的见解。此外，这些研究表明，microRNA 是治疗干预或生物标志物的绝佳候选者，用于在烧伤和其他胃肠道相关病理状况等创伤后管理肠道屏障完整性。本文回顾的研究重点关注在很大程度上影响肠道屏障完整性的 microRNA，并深入了解急性损伤中肠道屏障破坏的机制。
The gastrointestinal (GI) tract is a highly dynamic structure essential for digestion, nutrient absorption, and providing an interface to prevent gut bacterial translocation. In order to maintain the barrier function, the gut utilizes many defense mechanisms including proliferation, apoptosis, and apical junctional complexes. Disruption of any of these parameters due to injury or disease could negatively impact the intestinal barrier function and homeostasis resulting in increased intestine inflammation, permeability, bacterial dysbiosis, and tissue damage. MicroRNAs are small noncoding RNA sequences that are master regulators of normal cellular homeostasis. These regulatory molecules affect cellular signaling pathways and potentially serve as candidates for providing a mechanism of impaired gut barrier integrity following GI-related pathologic conditions, ethanol exposure, or trauma such as burn injury. MicroRNAs influence cellular apoptosis, proliferation, apical junction complex expression, inflammation, and the microbiome. Due to their widespread functional affiliations, altered expression of microRNAs are associated with many pathologic conditions. This review explores the role of microRNAs in regulation of intestinal barrier integrity. The studies reviewed demonstrate that microRNAs largely impact intestine barrier function and provide insight behind the observed adverse effects following ethanol and burn injury. Furthermore, these studies suggest that microRNAs are excellent candidates for therapeutic intervention or for biomarkers to manage gut barrier integrity following trauma such as burn injury and other GI-related pathologic conditions. The studies reviewed in this article focus on microRNAs that largely impact intestine barrier integrity and provide an insight into the mechanism underlying gut barrier disruption in acute injuries.
影响因子：
3.7
作者：
Li X;Rendon JL;Choudhry MA
通讯作者：
Choudhry MA