Cellular mechanisms of somatic stem cell aging.
Cellular mechanisms of somatic stem cell aging.
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DOI：
10.1016/b978-0-12-416022-4.00014-7
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发表时间：
2014
影响因子：
--
通讯作者：
Brack, Andrew S.
中科院分区：
文献类型：
--
作者：
Jung, Yunjoon;Brack, Andrew S.
组织的动态平衡和再生能力依赖于具有自我更新和分化能力的稀有体细胞群体。在衰老过程中，许多组织表现出再生能力的下降和干细胞功能的丧失。包括躯体干细胞在内的细胞已经进化出一系列的制衡机制来感知和修复细胞损伤，以最大限度地发挥组织功能。然而，在衰老过程中，保护正常细胞功能的机制开始失效。在这篇综述中，我们将讨论维持组织保真度和生物寿命的常见细胞机制如何影响躯体干细胞功能。我们将通过关注三个对年龄敏感的干细胞隔间：血液、神经和肌肉，突出定义衰老的上下文相关变化和共性。了解在不同干细胞隔间内运作的外在调节因子和内在效应因子之间的相互作用，可能对确定改善健康跨度和治疗与年龄相关的退行性疾病的策略具有重要意义。
Tissue homeostasis and regenerative capacity rely on rare populations of somatic stem cells endowed with the potential to self-renew and differentiate. During aging, many tissues show a decline in regenerative potential coupled with a loss of stem cell function. Cells including somatic stem cells have evolved a series of checks and balances to sense and repair cellular damage to maximize tissue function. However, during aging the mechanisms that protect normal cell function begin to fail. In this review, we will discuss how common cellular mechanisms that maintain tissue fidelity and organismal lifespan impact somatic stem cell function. We will highlight context-dependent changes and commonalities that define aging, by focusing on three age-sensitive stem cell compartments: blood, neural, and muscle. Understanding the interaction between extrinsic regulators and intrinsic effectors that operate within different stem cell compartments is likely to have important implications for identifying strategies to improve health span and treat age-related degenerative diseases.