Benzothiazoles - Scaffold of Interest for CNS Targeted Drugs
Benzothiazoles - Scaffold of Interest for CNS Targeted Drugs
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DOI：
10.2174/0929867322666141212120631
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发表时间：
2015-01-01
影响因子：
4.1
通讯作者：
Musilek, Kamil
中科院分区：
文献类型：
--
作者：
Hroch, Lukas;Aitken, Laura;Musilek, Kamil
苯并噻唑化合物代表杂环体系，其包含与在其结构中含有氮和硫的噻唑环稠合的苯环。除了在天然存在的分子中存在苯并噻唑核之外，在其结构中含有苯并噻唑部分的合成化合物被证明是一类重要的潜在治疗剂，因为它们表现出诸如抗肿瘤、抗菌、抗结核、抗病毒、驱虫、抗糖尿病等生物学效应。除了上述外周或微生物活性位点外，苯并噻唑类似物也是中枢神经系统中的生物活性化合物，其中已经鉴定了一些含有苯并噻唑部分的批准药物，并用于治疗各种神经系统疾病。新的苯并噻唑分子目前正在开发中，并且正在评估其几种用途，包括诊断和作为治疗癫痫和神经退行性疾病如阿尔茨海默病、亨廷顿病和肌萎缩性侧索硬化症等的治疗药物候选物。
Benzothiazole compounds represent heterocyclic systems comprising a benzene ring fused with a thiazole ring containing nitrogen and sulphur in its structure. Besides the presence of a benzothiazole core in naturally occurring molecules, synthesized compounds containing a benzothiazole moiety in their structure proved to be a significant class of potential therapeutics, as they exhibit biological effects such as antitumor, antibacterial, antitubercular, antiviral, anthelmintic, antidiabetic and many others. Apart from the aforementioned peripheral or microbial active sites, benzothiazole analogues are also biologically active compounds in the central nervous system, where some approved drugs containing a benzothiazole moiety have already been identified and are used in the treatment of various neurological disorders. New benzothiazole molecules are currently under development and are being evaluated for several uses including diagnostics and as therapeutic drug candidates for the treatment of epilepsy and neurodegenerative diseases such as Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis amongst others.