A functional nitric oxide reductase model
A functional nitric oxide reductase model
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DOI：
10.1073/pnas.0808606105
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发表时间：
2008-10-14
影响因子：
11.1
通讯作者：
Solomon, Edward I.
中科院分区：
文献类型：
--
作者：
Collman, James P.;Yang, Ying;Solomon, Edward I.
提出了一个血红素/非血红素一氧化氮还原酶（NOR）的功能模型。完全还原的二铁化合物与两当量的NO反应，导致形成一当量的N2 O和二铁产物。一氧化氮结合血红素铁和非血红素铁复合物形成个人亚铁亚硝酰基物种。具有氧化血红素和还原非血红素Fe-B的混合价物种不显示NO还原活性。这些结果与细菌NOR还原NO的所谓“反式”机制一致。
A functional heme/nonheme nitric oxide reductase (NOR) model is presented. The fully reduced diiron compound reacts with two equivalents of NO leading to the formation of one equivalent of N2O and the bis-ferric product. NO binds to both heme Fe and nonheme Fe complexes forming individual ferrous nitrosyl species. The mixed-valence species with an oxidized heme and a reduced nonheme Fe-B does not show NO reduction activity. These results are consistent with a so-called "trans" mechanism for the reduction of NO by bacterial NOR.