Imaging with radiolabelled monoclonal antibody (MUJ591) to prostate-specific membrane antigen in staging of clinically localized prostatic carcinoma: comparison with clinical, surgical and histological staging
Imaging with radiolabelled monoclonal antibody (MUJ591) to prostate-specific membrane antigen in staging of clinically localized prostatic carcinoma: comparison with clinical, surgical and histological staging
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DOI：
10.1111/j.1464-410x.2005.05511.x
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发表时间：
2005-06-01
影响因子：
4.5
通讯作者：
Britton, KE
中科院分区：
文献类型：
--
作者：
Nargund, V;Al Hashmi, D;Britton, KE
目的评价前列腺特异性膜抗原(PSMA)核素标记抗体(MUJ591)在早期前列腺癌分期中的可靠性。方法对16例耻骨后前列腺癌根治术患者进行前瞻性研究。所有患者均采用99m标记的MUJ591进行PSMA显像。结果7例患者的前列腺影像与组织学结果一致。结论99m标记MUJ591的PSMA核素显像可明确前列腺癌的存在，但对包膜、精囊或膀胱颈的微侵袭不敏感。与其他研究一样，它似乎对检测前列腺床复发和远处微转移很有用。
OBJECTIVETo evaluate the reliability of prostate scintigraphy using a radiolabelled antibody (MUJ591) raised against the external domain of prostate-specific membrane antigen [PSMA) in the staging of early prostate cancer,PATIENTS AND METHODSThis was a prospective study of 16 patients who had radical retropubic prostatectomies (median PSA 9.75 ng/mL). All patients underwent PSMA imaging using MUJ591 radiolabelled with Tc-99m using a photoreduction technique.RESULTS The findings of prostate imaging and histology were identical in seven patients. Scans showed understaging and overstaging in six and three patients, respectively.CONCLUSIONS PSMA scintigraphy using Tc-99m-labelled MUJ591 identifies the presence of prostate cancer, but is not sensitive in delineating micro-invasion of the capsule, seminal vesicles or bladder neck. As in other studies it seems to be useful in detecting prostate bed recurrence and distant micrometastasis.