CONTRIBUTION OF LOW-LEVEL HBV REPLICATION TO CONTINUING INFLAMMATORY ACTIVITY IN PATIENTS WITH ANTI-HBE POSITIVE CHRONIC HEPATITIS-B VIRUS-INFECTION
CONTRIBUTION OF LOW-LEVEL HBV REPLICATION TO CONTINUING INFLAMMATORY ACTIVITY IN PATIENTS WITH ANTI-HBE POSITIVE CHRONIC HEPATITIS-B VIRUS-INFECTION
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DOI：
10.1136/gut.25.11.1283
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发表时间：
1984-01-01
期刊：
影响因子：
24.5
通讯作者：
THOMAS, HC
中科院分区：
文献类型：
--
作者：
LOK, ASF;HADZIYANNIS, SJ;THOMAS, HC
对41例希腊和29例英国慢性HBV感染患者的组织学诊断与HBV [B型肝炎病毒]复制的血清学和组织标志物之间的关系进行了研究。所有9例希腊和13例英国患者的HBeAg [B e抗原]均阳性，血清中有HBV-DNA，肝细胞中有HBcAg [B核心抗原]表达。这些患者中的大多数（73%）患有活动性肝病。47%的希腊患者和19%的英国患者抗-HBe [抗-B e抗体]阳性，在血清中检测到或未检测到HBV-DNA的情况下，肝脏中继续显示HBcAg。除3例患者外，所有患者均患有持续活动性肝病。然而，在没有HBV复制证据的抗HBe阳性患者中也发现了31%的肝脏持续炎症活动。在这些患者中，其他因素如δ因子、非A、非B病毒、酗酒或HBV引发的自身免疫反应可能是促成因素。
The relationship between the histological diagnosis and serological and tissue markers of HBV [hepatitis B virus] replication in 41 Greek and 29 British patients with chronic HBV infection were studied. All the 9 Greek and 13 British patients who were HBeAg [hepatitis B e antigen] positive had HBV-DNA in serum and HBcAg [hepatitis B core antigen] expression in the hepatocytes. The majority (73%) of these patients had active liver disease. Forty-seven percent of the Greek and 19% of the British patients who were anti-HBe [anti-hepatitis B e antibody] positive continued to display HBcAg in the liver with or without HBV-DNA detected in serum. All but 3 of these patients had persistently active liver disease. Continuing inflammatory activity in the liver, however, was also found in 31% of anti-HBe positive patients who had no evidence of HBV replication. In these patients, other factors such as delta agent, non-A, non-B viruses, alcohol abuse or an autoimmune reaction initiated by HBV may be contributory.