The New Challenges of Brain PET Imaging Technology
The New Challenges of Brain PET Imaging Technology
复制标题
脑部PET成像技术的新挑战
DOI：
--
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Marie
中科院分区：
文献类型：
--
作者：
H. Zaidi;Marie
在过去的二十年里，使用正电子发射断层扫描(PET)的脑功能成像技术取得了长足的进步，并在临床和研究领域发挥着越来越重要的作用。不同的扫描仪制造商和研究小组在设计专用的高分辨率三维(3D)PET单元方面已经取得了重大进展；然而，新兴的临床和研究应用功能脑成像承诺更高水平的准确性和精密度，因此，对PET断层成像的内在性能施加了更多限制。不断努力整合最新的研究成果，以设计不同几何形状和各种探测器/读出技术的PET扫描仪，已成为学术界和核医学行业的目标。随着PET被整合到临床实践中，出现了几种设计趋势；系统现在具有一系列功能，从为“低成本”临床应用而设计的系统到专门为非常高分辨率的研究应用而设计的系统。所有这些系统的硬件和软件组件也在不断向上修订和改进。基于软件和硬件的解剖(x射线、CT、MRI)和生理(PET)信息之间的相关性是一个很有前途的研究领域，现在为医学成像界和生物医学研究人员提供了独特的能力。双模式PET/CT成像的主要优势之一是，PET数据本质上与来自X射线CT的解剖信息对齐，而无需使用外部标记或内部标志，从而提供用于衰减和散射校正目的的衰减图的可靠估计。另一方面，由于强磁场，将PET与MRI技术结合在一起在科学上更具挑战性。然而，已经取得了重大进展，导致了通过光纤耦合到三个多通道光电倍增管的小动物PET扫描仪的原型的设计，从而使PET探测器可以在传统的MR系统中操作。因此，在学术和企业环境中，许多不同的设计道路已经并将继续被追求，这些道路在性能方面提供了不同的权衡。目前还不确定哪些设计将被纳入未来的临床和研究系统，但可以肯定的是，技术进步将继续下去，并将在脑PET成像中实现新的定量能力。本文简要总结了专用脑PET仪器的最新进展。还将讨论未来的前景。
During the last two decades, functional brain imaging using positron emission tomography (PET) has advanced elegantly, and steadily gained importance in the clinical and research arenas. Significant progress has been made by different scanner manufacturers and research groups in the design of dedicated high-resolution three-dimensional (3-D) PET units; however, emerging clinical and research applications of functional brain imaging promise even greater levels of accuracy and precision and therefore, impose more constraints with respect to the intrinsic performance of the PET tomograph. Continuous efforts to integrate recent research findings for the design of different geometries and various detector/readout technologies of PET scanners have become the goal of both the academic community and nuclear medicine industry. As PET has become integrated into clinical practice, several design trends have developed; with systems now available with a spectrum of features, from those designed for "low cost" clinical applications to others designed specifically for very high-resolution research applications. There is also a continual upward revision and refinement in both hardware and software components for all of these systems. Software- and hardware-based correlation between anatomical (x-ray CT, MRI) and physiological (PET) information is a promising research field and now offers unique capabilities for the medical imaging community and biomedical researchers. One of the main advantages of dual-modality PET/CT imaging is that PET data are intrinsically aligned to anatomical information from the x-ray CT without the use of external markers or internal landmarks, thus providing a reliable estimate of the attenuation map to be used for attenuation and scatter correction purposes. On the other hand, combining PET with MRI technology is scientifically more challenging owing to the strong magnetic fields. Nevertheless, significant progress has been made resulting in the design of a prototype small animal PET scanner coupled to three multi- channel photomultipliers via optical fibers, so that the PET detector can be operated within a conventional MR system. Thus, many different design paths have been and continue to be pursued in both academic and corporate settings, that offer different trade-offs in terms of their performance. It still is uncertain which designs will be incorporated into future clinical and research systems, but it is certain that technological advances will continue and will enable new quantitative capabilities in brain PET imaging. This paper briefly summarizes state of the art developments in dedicated brain PET instrumentation. Future prospects will also be discussed.
登录
查看更多内容
基于 2 维和 3 维全身 PET 噪声当量计数率优化注射剂量。
DOI：
--
发表时间：
2002
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
影响因子：
--
作者：
Lartizien,Carole;Comtat,Claude;Kinahan,PaulE;Ferreira,Nuno;Bendriem,Bernard;Trebossen,Regine
通讯作者：
Trebossen,Regine
影响因子：
1.3
作者：
Woods, RP;Grafton, ST;Mazziotta, JC
通讯作者：
Mazziotta, JC
HEAD PENN-PET 扫描仪的三维成像特性。
DOI：
--
发表时间：
1997
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Karp,JS;Freifelder,R;Geagan,MJ;Muehllehner,G;Kinahan,PE;Lewitt,RM;Shao,L
通讯作者：
Shao,L
用于脑成像的正电子断层扫描仪的性能评估。
DOI：
--
发表时间：
1983
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Hoffman,EJ;Phelps,ME;Huang,SC
通讯作者：
Huang,SC
一项病变检测观察者研究，比较 2 维与全 3 维全身 PET 成像方案。
DOI：
--
发表时间：
2004
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Lartizien,Carole;Kinahan,PaulE;Comtat,Claude
通讯作者：
Comtat,Claude