The unsolved mystery of apoA-I recycling in adipocyte.
The unsolved mystery of apoA-I recycling in adipocyte.
复制标题
脂肪细胞中 apoA-I 回收的未解之谜。
DOI：
10.1186/s12944-016-0203-x
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发表时间：
2016-02-24
影响因子：
4.5
通讯作者：
Yi Y
中科院分区：
文献类型：
--
作者：
Wang S;Peng DQ;Yi Y
脂肪组织作为甘油三酯和游离胆固醇的主要储存部位，在能量代谢中起着核心作用。ApoA-I是HDL的主要成分，在清除外周组织中多余的胆固醇中起重要作用。近年来，多项研究表明apoa - 1对脂肪代谢和功能有有益作用。在动物实验中，apoa - 1有改善胰岛素敏感性和抗炎、抗肥胖的作用。有趣的是，已经检测到脂肪细胞对apoA-I的摄取和排泄。然而，apoA-I被脂肪细胞回收的意义尚不清楚。本文综述了apoA-I细胞循环利用的研究方法，并对脂肪细胞摄取apoA-I的机制进行了综述。由于apoA-I的主要功能是介导胆固醇从外周组织的逆向转运，因此我们讨论了apoA-I的内化和脂肪细胞的再分泌在生理和病理条件下细胞内胆固醇转运中的作用。此外，还讨论了apoA-I循环与肥胖之间的关系。最后，我们提出在细胞内运输过程中，apoa - i蛋白复合物可能获得脂质以外的货物，并在它们被重分泌到血浆中时传递调节信息。尽管脂肪细胞对apoA-I的再循环仍然是一个未解之谜，但它很可能不仅仅是一个冗余途径，尤其是在病理条件下。
As the major storage site for triglycerides and free cholesterol, adipose tissue plays a central role in energy metabolism. ApoA-I is the main constituent of HDL and plays an important role in removal of excess cholesterol from peripheral tissues. Recently, multiple studies have shown beneficial effects of apoA-I on adipose metabolism and function. ApoA-I was reported to improve insulin sensitivity and exert anti-inflammatory, anti-obesity effect in animal studies. Interestingly, Uptake and resecretion of apoA-I by adipocytes has been detected. However, the significance of apoA-I recycling by adipocytes is still not clear. This article reviewed methods used to study cellular recycling of apoA-I and summarized the current knowledge on the mechanisms involved in apoA-I uptake by adipocytes. Since the main function of apoA-I is to mediate reverse cholesterol transport from peripheral tissues, the role of apoA-I internalization and re-secretion by adipocytes in intracellular cholesterol transport under physiological and pathological conditions were discussed. In addition, findings on the correlation between apoA-I recycling and obesity were discussed. Finally, it was proposed that during intracellular transport, apoA-I-protein complex may acquire cargoes other than lipids and deliver regulatory information when they were resecreted into the plasma. Although apoA-I recycling by adipocytes is still an unsolved mystery, it’s likely that it is more than a redundant pathway especially under pathological conditions.