Fascin: A key regulator of cytoskeletal dynamics
Fascin: A key regulator of cytoskeletal dynamics
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DOI：
10.1016/j.biocel.2010.06.019
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发表时间：
2010-10-01
影响因子：
4
通讯作者：
Parsons, Maddy
中科院分区：
文献类型：
--
作者：
Jayo, Asier;Parsons, Maddy
Fasin是一种55 kDa的肌动蛋白捆绑蛋白，在多种细胞环境中维持平行的丝状肌动蛋白束的稳定性是一个重要的调节元件。筋膜蛋白功能的调节受许多不同的信号通路的控制，这些信号通路协同作用，在空间上调节该蛋白质的肌动蛋白结合特性。筋膜蛋白结合和捆绑肌动蛋白的能力在调节细胞的黏附、迁移和侵袭过程中起着核心作用。近年来，作为一种新的转移性疾病的关键预后标志物，筋膜蛋白受到了相当大的关注。目前正在进行研究，以更好地了解这种蛋白质在肿瘤进展过程中的精确调控，并研究Fasin作为多种形式癌症的潜在治疗靶点。(C)2010爱思唯尔有限公司。保留所有权利。
Fascin is a 55 kDa actin-bundling protein and is an important regulatory element in the maintenance and stability of parallel bundles of filamentous actin in a variety of cellular contexts. Regulation of fascin function is under the control of a number of different signalling pathways that act in concert to spatially regulate the actin-binding properties of this protein. The ability of fascin to bind and bundle actin plays a central role in the regulation of cell adhesion, migration and invasion. Fascin has received considerable attention recently as an emerging key prognostic marker of metastatic disease. Studies are now underway to better understand the precise regulation of this protein in the context of tumour progression and to investigate fascin as a potential therapeutic target for a number of forms of cancer. (c) 2010 Elsevier Ltd. All rights reserved.