Thymus pathology observed in the MGTX trial
Thymus pathology observed in the MGTX trial
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DOI：
10.1111/j.1749-6632.2012.06799.x
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Stroebel, Philipp
中科院分区：
文献类型：
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作者：
Marx, Alexander;Pfister, Frederik;Stroebel, Philipp
The MGTX trial is the first prospective, randomized clinical trial that aims to evaluate the impact of extended transsternal thymectomy on myasthenic symptoms, prednisone requirements, and quality of life in patients with non-thymomatous, anti-acetylcholine receptor autoantibody-positive myasthenia gravis (MG). Here, we give an overview of the rationale of thymectomy and the standardized macroscopic and histopathological work-up of thymectomy specimens as fixed in MGTX standard operating procedures, including the grading of thymic lymphofollicular hyperplasia and the morphometric strategy to assess thymic involution.
