Serotonin modulates locomotory behavior and coordinates egg-laying and movement in Caenorhabditis elegans
Serotonin modulates locomotory behavior and coordinates egg-laying and movement in Caenorhabditis elegans
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DOI：
10.1002/neu.10014
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发表时间：
2001-12-01
期刊：
影响因子：
--
通讯作者：
Schafer, WR
中科院分区：
文献类型：
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作者：
Hardaker, LA;Singer, E;Schafer, WR
生物胺参与了多种生物体中涉及不同行为的神经回路的调节。在线虫C elegans中，5-羟色胺已被证明可以调节产卵行为的时间模式。在这里，我们表明，血清素能神经传递也是调节与运动相关的行为事件的时间以及协调运动行为与产卵所必需的。使用自动跟踪系统记录运动行为在很长一段时间内，我们确定，无论是运动的方向和速度波动在一个随机模式在野生型蠕虫。在活跃的产卵期间，反转和速度的模式被改变：速度增加短暂的产卵事件之前，而反转增加的频率后，产卵事件。产卵和运动之间的时间协调依赖于HSN产卵运动神经元和AVF中间神经元，它们接受HSN的突触输入。5-羟色胺缺乏突变体也未能协调产卵和运动，并表现出异常低的整体逆转频率。因此，5-羟色胺的功能似乎是在活跃的产卵期间促进运动的增加，并且通常用于调节促进向前运动的决策神经元。(C)John Wiley & Sons，Inc.
Biogenic amines have been implicated in the modulation of neural circuits involved in diverse behaviors in a wide variety of organisms. In the nematode C elegans, serotonin has been shown to modulate the temporal pattern of egg-laying behavior. Here we show that serotonergic neurotransmission is also required for modulation of the timing of behavioral events associated with locomotion and for coordinating locomotive behavior with egg-laying. Using an automated tracking system to record locomotory behavior over long time periods, we determined that both the direction and velocity of movement fluctuate in a stochastic pattern in wild-type worms. During periods of active egg-laying, the patterns of reversals and velocity were altered: velocity increased transiently before egg-laying events, while reversals increased in frequency following egg-laying events. The temporal coordination between egg-laying and locomotion was dependent on the serotonergic HSN egg-laying motorneurons as well as the decision-making AVF interneurons, which receive synaptic input from the HSNs. Serotonin-deficient mutants also failed to coordinate egg-laying and locomotion and exhibited an abnormally low overall reversal frequency. Thus, serotonin appears to function specifically to facilitate increased locomotion during periods of active egglaying, and to function generally to modulate decisionmaking neurons that promote forward movement. (C) 2001 John Wiley & Sons, Inc.