Cyclosporine-induced alterations of humoral response in experimental autoimmune uveitis.
Cyclosporine-induced alterations of humoral response in experimental autoimmune uveitis.
复制标题
环孢素诱导的实验性自身免疫性葡萄膜炎体液反应的改变。
DOI：
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发表时间：
1984
影响因子：
4.4
通讯作者：
R. Nussenblatt
中科院分区：
文献类型：
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作者：
C. Chan;A. Palestine;R. Nussenblatt
环孢素 (CsA) 已被证明可有效预防 Lewis 大鼠中 S 抗原 (S-Ag) 诱导的实验性自身免疫性葡萄膜炎 (EAU)。与 CsA 治疗相关的体液免疫反应的变化通过循环抗 S-Ag 抗体的峰值较低和延迟产生来说明，与 EAU 中 CsA 的剂量成比例关系。在患有 EAU 的大鼠或接受 CsA 治疗但未患病的大鼠中未检测到循环免疫复合物。这些发现进一步支持了 T 细胞在 EAU 中的重要作用，并进一步证明了 CsA 对辅助 T 细胞的影响。 S-Ag 免疫大鼠产生抗体的动力学似乎被 CsA 改变。
Cyclosporine (CsA) has been shown to be effective in preventing S-antigen (S-Ag) induced experimental autoimmune uveitis (EAU) in Lewis rats. Alterations in the humoral immune responses associated with CsA therapy are illustrated by lower peak and delayed production of circulating anti-S-Ag antibodies in a proportional relationship to the dose of CsA in EAU. Circulating immune complexes were not detected in rats with EAU or in rats treated with CsA and without disease. These findings further support the important role of T-cells in EAU and further demonstrate the effect of CsA on helper T-cells. The kinetics of antibody production by S-Ag-immunized rats appears altered by CsA.