Antibody neutralization of retargeted measles viruses.
Antibody neutralization of retargeted measles viruses.
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DOI：
10.1016/j.virol.2014.01.027
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发表时间：
2014-04
期刊：
影响因子：
3.7
通讯作者：
Russell, Stephen J.
中科院分区：
文献类型：
--
作者：
Lech, Patrycja J.;Pappoe, Roland;Nakamura, Takafumi;Russell, Stephen J.
关键词：
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The measles virus (MV) vaccine lineage is a promising oncolytic but prior exposure to the measles vaccine or wild-type MV strains limits treatment utility due to the presence of anti-measles antibodies. MV entry can be redirected by displaying a polypeptide ligand on the Hemagglutinin (H) C-terminus. We hypothesized that retargeted MV would escape neutralization by monoclonal antibodies (mAbs) recognizing the H receptor-binding surface and be less susceptible to neutralization by human antisera. Using chimeric H proteins, with and without mutations that ablate MV receptor binding, we show that retargeted MVs escape mAbs that target the H receptor-binding surface by virtue of mutations that ablate infection via SLAM and CD46. However, C-terminally displayed domains do not mediate virus entry in the presence of human antibodies that bind to the underlying H domain. In conclusion, utility of retargeted oncolytic measles viruses does not extend to evasion of human serum neutralization.
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