Alternative methods in toxicology: pre-validated and validated methods.
Alternative methods in toxicology: pre-validated and validated methods.
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DOI：
10.2478/v10102-011-0018-6
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发表时间：
2011-09
影响因子：
--
通讯作者：
Letašiová S
中科院分区：
文献类型：
--
作者：
Kandárová H;Letašiová S
过去 20 年来，动物实验替代方法的开发进展迅速。如今，体外和计算机方法在化合物毒理学特征的危害识别和评估中发挥着重要作用。先进的替代方法及其组合也用于最终产品的安全评估。几种经过科学验证并被主管监管机构接受的替代方法可用于监管毒理学目的，从而减少或完全替代毒理学实验中的活体动物。包括 OECD、FDA 和 EPA 在内的监管机构已认可替代方法作为现代毒理学的宝贵工具。本文简要概述了“毒理学替代方法”主题，重点介绍了预先验证和验证的替代方法及其在现代毒理学中的地位。
The development of alternative methods to animal experimentation has progressed rapidly over the last 20 years. Today, in vitro and in silico methods have an important role in the hazard identification and assessment of toxicology profile of compounds. Advanced alternative methods and their combinations are also used for safety assessment of final products. Several alternative methods, which were scientifically validated and accepted by competent regulatory bodies, can be used for regulatory toxicology purposes, thus reducing or fully replacing living animals in toxicology experimentation. The acceptance of the alternative methods as valuable tools of modern toxicology has been recognized by regulators, including OECD, FDA and EPA. This paper provides a brief overview of the topic “alternative methods in toxicology” and focuses on pre-validated and validated alternative methods and their position in the modern toxicology.