Smartphone-integrated ratiometric fluorescence sensing platform based on bimetallic metal–organic framework nanowires for anthrax biomarker detection
Smartphone-integrated ratiometric fluorescence sensing platform based on bimetallic metal–organic framework nanowires for anthrax biomarker detection
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DOI：
10.1007/s00604-023-06065-7
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发表时间：
2023-11
影响因子：
5.7
通讯作者：
Ting Wang;Jieyuan Zhang;Yue Wu;Shiyi Wang;Xinhui Jiang;Zhengwei Zhang;Siqiao Li
中科院分区：
文献类型：
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作者：
Ting Wang;Jieyuan Zhang;Yue Wu;Shiyi Wang;Xinhui Jiang;Zhengwei Zhang;Siqiao Li
开发一种智能、灵敏和可视化的策略来快速识别炭疽生物标记物，对于确保食品安全和预防疾病暴发至关重要。为此，设计了一种基于双金属金属有机骨架(eux/Tb1-x-MOF)纳米线的智能手机集成比率荧光传感平台，用于对吡啶-2，6-二元酸(DPA，炭疽生物标记物)的特异性识别。通过将Eu3+和Tb3+与BBDC配位，制备了Eux/Tb1-x-MOF，其具有均匀的纤维形态和543 nm和614 nm的双发射荧光。引入DPA后，614 nm处的红光发射表现出明显的荧光猝灭，而543 nm处的绿光发射也逐渐增强。该方法的线性范围为0.06~15微克/毫升，检出限为20.69微克/毫升。此外，安装了颜色识别应用程序的便携式智能手机可以实现对DPA的灵敏、实时和可视检测。作为一个简单而有效的智能手机辅助传感平台，这项工作有望在生物标志物实时检测等领域扩大应用。
Developing an intelligent, sensitive, and visual strategy for quickly identifying anthrax biomarkers is crucial for ensuring food safety and preventing disease outbreaks. Herein, a smartphone-integrated ratiometric fluorescent sensing platform based on bimetallic metal–organic framework (Eux/Tb1-x-MOF) nanowires was designed for specific recognition of pyridine-2,6-dicarboxylic acid (DPA, anthrax biomarker). The Eux/Tb1-x-MOF was prepared by coordinating Eu3+and Tb3+with BBDC ligands, which exhibited a uniform fibrous morphology and dual-emission fluorescence at 543 and 614 nm. After the introduction of DPA, the red emission at 614 nm displayed obvious fluorescence quenching, while the green emission at 543 nm was gradually enhanced. The ratiometric sensing offered a wide linear equation in the range of 0.06–15 µg/mL and a low detection limit (LOD) of 20.69 ng/mL. Furthermore, a portable smartphone installing the color recognition application can achieve sensitive, real-time, and visual detection of DPA. As a simple and effective smartphone-assisted sensing platform, this work holds admirable promise to broaden the applications in biomarker real-time determinations and other fields.Graphical Abstract