NUCLEAR HORMONE RECEPTORS ACTIVATE DIRECT, INVERTED, AND EVERTED REPEATS
NUCLEAR HORMONE RECEPTORS ACTIVATE DIRECT, INVERTED, AND EVERTED REPEATS
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DOI：
10.1111/j.1749-6632.1995.tb31366.x
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发表时间：
1995-01-01
期刊：
影响因子：
--
通讯作者：
EVANS, RM
中科院分区：
文献类型：
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作者：
FORMAN, BM;EVANS, RM
核激素受体包括将细胞应答与细胞外和细胞内信号联系起来的配体调节的转录因子家族。类维生素A、甲状腺激素、维生素D3和脂肪酸/过氧化物酶体增殖物的受体将其反应元件作为异二聚体与类维生素A X受体结合。天然存在的反应元件由组织为直接、反向和/或外翻重复的核心基序组成。促进单个受体异源二聚体与这些不同结合位点结合的结构机制仍然未知。
Nuclear hormone receptors comprise a family of ligand-modulated transcription factors that link cellular responses to extracellular and intracellular signals. Receptors for retinoids, thyroid hormone, vitamin D3 and fatty acids/peroxisome proliferators bind their response elements as heterodimers with the retinoid X receptor. Naturally occurring response elements are composed of core-motifs that are organized as direct, inverted, and/or everted repeats. The structural mechanisms that facilitate binding of a single receptor heterodimer to such diverse binding sites remain unknown.