Complexity Analysis of Spontaneous Brain Activity in Attention-Deficit/Hyperactivity Disorder: Diagnostic Implications
Complexity Analysis of Spontaneous Brain Activity in Attention-Deficit/Hyperactivity Disorder: Diagnostic Implications
复制标题
DOI：
10.1016/j.biopsych.2008.10.046
复制
发表时间：
2009-04-01
影响因子：
10.6
通讯作者：
Ortiz, Tomas
中科院分区：
文献类型：
--
作者：
Fernandez, Alberto;Quintero, Javier;Ortiz, Tomas
背景：注意缺陷/多动障碍（ADHD）被定义为儿童最常见的神经行为障碍，但迄今为止还没有一个客观的诊断测试。神经心理学、神经影像学和神经生理学的研究为多动症患者的大脑和行为功能障碍提供了充足的证据，但这些发现还不能作为诊断测试。方法：对14例ADHD患者和14例健康儿童静息状态下的全头部脑磁图进行记录。获得每个通道和儿童的Lempel-Ziv复杂度（LZC）值，并在五个传感器组（前、中、左外侧、右外侧和后）中取平均值。结果：对照组的Lempel-Ziv复杂性评分显著高于对照组，且前区得分最高。结合年龄和前路复杂性值，可以以93%的敏感性和79%的特异性对ADHD患者和对照组进行正确的分类。在所有传感器组中，对照组的LZC得分均表现出与年龄相关的单调增加，而ADHD儿童的LZC得分则表现出不显著的下降趋势。年龄相关的差异导致9岁以上儿童的特异性为100%。结论：结果支持额叶活动减少在ADHD诊断中的作用。此外，ADHD患者和对照组之间复杂性评分的年龄相关差异可能反映了不同的发展轨迹。我们的结果的这种解释与最近的研究报告一致，报告了前额皮质皮层成熟的延迟。
Background: Attention-deficit/hyperactivity disorder (ADHD) is defined as the most common neurobehavioral disorder of childhood, but an objective diagnostic test is not available yet to date. Neurophychological, neuroimaging, and neurophysiological research offer ample evidence of brain and behavioral dysfunctions in ADHD, but these findings have not been useful as a diagnostic test.Methods: Whole-head magnetoencephalographic recordings were obtained from 14 diagnosed ADHD patients and 14 healthy children during resting conditions. Lempel-Ziv complexity(LZC) values were obtained for each channel and child and averaged in five sensor groups: anterior, central, left lateral, right lateral, and posterior.Results: Lempel-Ziv complexity scores were significantly higher in control subjects, with the maximum value in anterior region. Combining age and anterior complexity values allowed the correct classification of ADHD patients and control subjects with a 93% sensitivity and 79% specificity. Control subjects showed an age-related monotonic increase of LZC scores in all sensor groups, while children with ADHD exhibited a nonsignificant tendency toward decreased LZC scores. The age-related divergence resulted in a 100% specificity in children older than 9 years.Conclusions: Results support the role of a frontal hypoactivity in the diagnosis of ADHD. Moreover, the age-related divergence of complexity scores between ADHD patients and control subjects might reflect distinctive developmental trajectories. This interpretation of our results is in agreement with recent investigations reporting a delay of cortical maturation in the prefrontal cortex.